Accutane (Isotretinoin 5 mg)
€58.90 – €216.90
Generic Accutane is the medication based on Isotretinoin and identical to Accutane but simply made by another company. It is a medication used in severe cases of acne when no other means are effective. The medication can be used by teenagers older than twelve years and adults but is strictly contraindicated during pregnancy and women of childbearing age must use strict birth control means to minimize the chance of pregnancy while using the drug. Find out more about its use and efficacy from our guide below.
What is the medication sold under the name Accutane?
Accutane is a brand name registered for the medication Isotretinoin that has an anti-inflammatory, anti-seborrheic, derma protective and anti-acne action. The brand is owned by the first company who developed the active ingredient and started marketing it, a Swiss pharmaceutical company Hoffmann-La Roche AG. The studies on the active ingredient started back in the 1960s but the drug was approved for the above-mentioned uses only in the mid-eighties of the twentieth century. As you have probably guessed since there are available generic versions of the medicine, the right to make this medication exclusively by its developer had already expired which means that other pharmaceutical concerns and even small companies can use the formula and make their own drugs. For consumers, it means that they can buy Accutane much cheaper if they opt for Isotretinoin made by another company. Read further to know how to find the right drug, where to buy it cheaper, and how to use it properly without suffering from adverse effects.
When is Accutane used?
The medication comes in different formulations – oral pills, rectal suppositories, and ointments. The tablets we offer you to purchase at this webpage are suitable for the therapy of severe acne and in particular nodular and conglobate acne, acne with a tendency to leave scars, and in general acne that are not effectively treated with the standard treatment methods such as systemic antibiotic therapy and topical treatment.
The topical products based on Isotretinoin are used for acne vulgaris, seborrheic dermatitis, rosacea, and perioral dermatitis.
You should know that Isotretinoin is a potent medication that can interfere with many vital processes and functions of the body. Therefore, you should buy Generic Accutane only if you discuss it with your doctor and he or she approves.
Is it suitable to buy Generic Accutane instead of the brand drug?
As we have previously mentioned, currently, the formula of the brand medication can be used by virtually all pharmaceutical companies since the exclusive right of its developer is expired. These drugs made by other companies are cheaper because they are less advertised and because their makers didn’t invest in the development of the drug.
There are absolutely no counter-arguments against using generic versions of the medicine since they are identical to the brand drug, of course, if you get the product from a reliable drugstore and manufacturer. Besides, in the U.S. you cannot even purchase the brand drug since the company had withdrawn its product from the market after it got sued based on allegations that Accutane provokes irritable bowel syndrome development which is one of the possible side effects of the drug but it doesn’t mean that it develops in anyone. But now, in the U.S. drugstores, you can buy Generic Isotretinoin only which is not that bad considering that they are the same drugs simply priced cheaper.
When must not Generic Accutane be used?
The intake of the medication orally and the use of rectal suppositories is contraindicated in the presence of hypersensitivity to the drug’s components. Besides, it must not be used during pregnancy and when the pregnancy is planned, during breastfeeding, liver dysfunction, in hypervitaminosis with vitamin A, and severe hyperlipidemia.
If you plan to use the suppositories, you should also check that you don’t have any bowel diseases.
If you plan to use ointments based on Isotretinoin, you can use it while being pregnant, planning a pregnancy, or while breastfeeding but on small areas of skin.
If you are diagnosed with diabetes, depression (during history), obesity, violation of lipid metabolism, or alcoholism, you must get tested and consult a qualified specialist whether you can buy Isotretinoin and use it or not and if you can, then how should you use it to avoid any harm.
How does Generic Accutane act?
The precise principle of the active agent action is still unknown in detail but it was identified that an betterment of pronounced and difficultly treated forms of acne is related to a diminishing in sebaceous gland function and their size. It happens due to the normalization of terminal differentiation of cells, inhibition of the proliferation of the sebaceous glands ducts epithelium, the formation of detritus and facilitating of its evacuation. Besides, it is proven the preparation has an anti-inflammatory effect.
The preparation is differently absorbed and the bioavailability of it is also variable in different people. The intake of the pills with food contributes to the twofold elevation of the amount of the drug that is active after the intake. The max amount of the substance in the blood is achieved within two-four hours after the pills intake. The preparation is excreted in bile and urine in about the same parts.
Precautions to follow when you use Generic Accutane
When you order Accutane you should be ready that in the course of the therapy you would need to monitor the level of lipids, glucose, and liver function. People who are diagnosed with diabetes should monitor blood glucose more frequently when undergoing the therapy.
Women of fertile age should acknowledge that the medication is very dangerous for the fetus. Therefore, while undergoing the therapy, they need to do pregnancy tests before the start of the therapy and begin using the drug only if the test is negative. Besides, it is encouraged to use at least two different birth control methods including condom to avoid pregnancy while using Generic Accutane. If pregnancy still occurs, medical abortion must be made. The pregnancy test must be also done five weeks after the therapy is discontinued and if pregnancy occurs within this time, you must immediately notify a doctor. Besides, it is important to document the dates when pregnancy tests are made and when you started using Isotretinoin-based medication.
In the event of colitis development, visual impairment and/or symptoms of the pseudo-tumor are observed while the treatment is undergone, it must be immediately is stopped. If a pseudotumor of the brain is suspected, a neurologic examination is performed. You must not use medication if you already use other medications from the retinoid group to avoid hypervitaminosis A.
During the therapy, it is important to avoid direct or long exposure to the sunlight.
How should you take Generic Accutane?
The therapy with the preparation must be appointed by the doctor who has the experience of treating their patients with drugs from the retinoid group from severe acne and is fully aware of the risks of retinoid therapy and the process of correct examination of the patient’s condition. Make sure to find such professional before you order Accutane and start using it to ensure your safety.
The tablets are taken orally during the meals one or two times a day.
Adults (including teens older than twelve years and elderly patients) are usually advised to initiate the course with 0.5 mg per kilogram of the body weight a day. The effect and the occurrence of adverse effects are contingent on the personal tolerance of the medicine which is why a healthcare provider should adjust the dose respectively during the therapy. Usually, the effective and safe dose in the majority of patients is from 0.5 mg to 1 mg per kilogram of the body weight a day.
The complete curing and the likelihood/frequency of relapses are more dependent on the total prescribed dose than with the length of treatment or the daily dose. It is proved that it is wrong to expect an additional benefit at the application of a course dose above 120-150 mg per kg of body weight. The length of the therapy course is contingent on the daily dose. To cure acne, usually, a course of treatment of sixteen to twenty-four weeks is enough.
In the majority of people, the acne elimination forever is achieved after one treatment course. If a severe relapse happens, it is necessary to undergo another treatment course with the same daily and total course dose as the first one. However, since the improvement can still happen within eight weeks after the complete course, it is recommended not to repeat the therapy earlier than this period of time after the first course passed.
Dosage adjustments for different groups of patients
People with severe kidney dysfunction should start the therapy with the lower daily dose, for instance, 10 mg a day. Then, the dose can be gradually raised by 1 mg per kilogram of the body weight till the maximum well-tolerated dose.
People who start suffering from severe adverse effects in the use of recommended doses should continue the treatment with lower doses. However, they should know that in this case the duration of the therapy will be longer and the risk of relapse is higher. To enjoy the highest efficacy, the highest well-tolerated dosage must be used.
Adverse effects associated with Generic Accutane use
Before you order Isotretinoin, you should be informed that the use of this medication can cause such adverse reactions as fatigue, headache, elevated intracranial pressure, nausea, vomiting, impaired vision, swelling of the optic nerve, seizures, photophobia, impaired dark adaptation, mental disorders, eye irritation, hearing impairment, dryness of the mouth, gums bleeding, diarrhea, inflammation of the bowel, pancreas dysfunction, rashes, itching, thinning of hair and reversible hair loss, and others.
You should also now that at the start of the course, there may be a worsening of acne that lasts for several weeks.
The most dangerous side effect of the medication is related to its effect on the fetus. It causes severe developmental anomalies, so it cannot be indicated for use in pregnant women.
Generic Accutane interactions
Before you order Generic Isotretinoin, make sure to check that you are not using any medicines it interacts with:
The intake of Accutane with other retinoid medicines elevates the risk of hypervitaminosis A.
It is prohibited to combine Isotretinoin with tetracycline antibiotics as these drugs both contribute to the elevation of the intracranial pressure.
The medication can lower the effect of progesterone; thus, during the treatment, birth control pills that contain progesterone should not be used.
The concurrent use with the medicines that enhance sensitivity to sunlight elevates the risk of sunburns.
The efficacy of the ointment based on Isotretinoin when applied along with the use of antibiotics of the tetracycline group, as well as topical application of glucocorticoids is lowered.
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