Actos (Pioglitazone 15 mg)
€39.80 – €112.80
Actos is a branded medication based on Pioglitazone. The generic versions of the medication are absolutely the same but cost cheaper because they are made by other companies. The medication is used as an additional therapy of diabetes type 2 when the effect of the first-line medications is insufficient or if they cannot be used for various reasons such as allergy to the main substance, contraindications for their use, and so on. The medication can be used in adults even with severe kidney impairment but not in children. It comes in different dosages per pill and the therapy must be started with the lowest one. Find out more about how to take the pills properly and enjoy their effect to the fullest from our comprehensive medication guide.
Brand name: Actos
Generic name: Pioglitazone
Indications: Monotherapy of diabetes type 2, Additional therapy of diabetes type 2
Benefits: The medication lowers the level of sugar in the blood even when other medicines or diet do not work
Analogs: Dibizone, Piolgem, Piosys, Actost, Pioglitazona
Generic Actos (Pioglitazone 15 mg) guide:
What is the medication called Actos?
The medication marketed as Actos is based on the active ingredient called Pioglitazone. It was developed in the late 1990s along with other medicines from the class of thiazolidinediones. The medications are used to lower the level of sugar in the blood through the increase of sensitivity to insulin. The preparation can be used as a single drug or in a combination therapy of diabetes of type two. Currently, it is also made by another drug manufacturing companies and therefore can be found under different trademarks.
The preparations based on Pioglitazone selectively stimulate the certain receptors which are activated by peroxisome proliferator, modulate the transcription of genes sensitive to insulin that participate in the control of glucose and metabolism of lipids in fatty and muscle tissue, as well as in the liver. They do not stimulate the secretion of insulin yet show activity only with the preserved insulin-synthetic function of the pancreas. Pioglitazone lowers the insulin resistance of peripheral tissues and liver, increases the consumption of insulin-dependent glucose, reduces the outcome of glucose from the liver; reduces the level of glucose, insulin and glycosylated hemoglobin in the blood. In people with impaired lipid metabolism, the preparation decreases the level of triglycerides and increases high-density cholesterol level without changing the total cholesterol and low-density lipoproteins level. Therefore, you can be prescribed to buy Actos as a single medication if you suffer both from high blood sugar and low level of “good” cholesterol.
According to the data from clinical trials, the medications based on Pioglitazone do not cause carcinogenic and mutagenic effects and don’t influence fertility.
The medication can be found in the blood thirty minutes after the pill intake. The maximum concentration is achieved within two hours after the pill intake, though the food intake inhibits the absorption and if you took the pill with food, the maximum concentration of the medication in the blood and its maximum effect respectively will be achieved within three to four hours. The medication is excreted in bile in unchanged form and in a form of metabolites. It is washed out of the body with feces and urine.
What is the difference between the branded medicine and Generic Actos? Can you buy Generic Actos instead of the branded medication?
You can without any doubts buy Generic Actos if your healthcare provider prescribes you the branded medication because the generic is basically the same drug just made by another company. However, if you order the medication from an online drugstore, you should pay attention to the name of the active substance and the dosage per pill. The name of the active substance is always indicated on the package of pills. In the case of Actos and its generics, it is Pioglitazone. Next, the medication comes in different dosages per pill – 15 mg, 30 mg, and 45 mg. Make sure to order the correct dosage that your doctor prescribed not to divide the pills for the correct dose intake as it can lower their effectiveness.
More and more people prefer to buy Generic Pioglitazone over the branded medication because it has absolutely the same composition and renders the same effect yet costs several times less money. The reason for the lower price is not the inferior quality but the fact that generic drug manufacturers do not develop the medicines themselves but get the right to make them either when the exclusive patent expires or when the patent stipulates that the formula must be shared with other makers of medicines.
When can you buy Actos or its generics?
Without any doubts, even if you suffer from the condition for which the medication is used, you need to consult a specialist before you buy Pioglitazone and start using the medication. First of all, you can suffer from other conditions in which this medicine is contraindicated, secondly, you may already use the medicines with similar effect and the combined effect will lead to the negative effects for your body. Below you can find the general recommendations for the medication use taken from the official instruction.
Pioglitazone-based medications are prescribed to be taken as a single-drug therapy or a combined therapy with derivatives of sulfonamides, metformin or insulin in the absence of the effect of diet therapy, exercise, and monotherapy by one of the above means and medicines. The medications are not the first drugs of choice for the condition treatment. They are usually prescribed as a single-drug therapy or an addition to the first-line therapy for people with excessive body weight whom metformin is contraindicated or who are allergic to it, who are allergic to other first-line medicines or cannot achieve sufficient blood sugar lowering effect with diet, exercise, and the intake of the medicines.
For whom Actos is contraindicated?
The preparation must not be taken by people who are hypersensitive or allergic to the medication, people who suffer from diabetes type one, diabetic ketoacidosis, severe heart failure, liver disease in the acute stage, level of alanine aminotransferase exceeding the norm by 2.5 times, during pregnancy and breastfeeding.
It is not advised to order Actos and use it for the treatment of people who suffer from swelling, anemia, or are younger than eighteen years.
What negative symptoms can the medication use cause?
The intake of the pills can be accompanied by headache, sinusitis, hypoglycemia, myalgia, pharyngitis, swelling, abnormality of teeth, and liver dysfunction.
Consult your doctor before you order the pills to know how to react in the occurrence of one or another negative reaction.
Interaction with other medications
Derivatives of sulfonamides, metformin and insulin potentiate (mutually) hypoglycemic (sugar lowering effect) of the medication.
Possible decrease in the effectiveness of oral contraception can be noticed when the medication is taken along with them.
The inductors of the CYP2C8 enzyme can influence the effectiveness of the medication and the dosage adjustment of Actos/Generic Actos can be required.
If you use any medicines, please consult your doctor about the safety of their use with this anti-diabetes medication before you order Generic Actos.
How to use Generic Actos?
If your healthcare provider gave you the precise instructions on how to use the pills you should follow them when you purchase a generic version of the medication with the right dosage of the active ingredient per pill.
After you started the therapy with the medication, every three-six months the effectiveness of the therapy must be assessed by a doctor. If the expected response from the therapy is not achieved, the use of the medication must be stopped. The treatment should be carried out in combination with diet and exercise, under the control of the level of glycosylated hemoglobin.
Here you can find the generally recommended instructions on the use of Actos adapted from the official instruction.
The pills should be taken by adults only. The regular dosage is once a day regardless of the meals intake. The tablet should be swallowed without chewing with a glass of water.
The initial dosage is 15 or 30 mg a day. If necessary, the dosage can be increased to 45 mg taken once a day.
In combination therapy with the use of Pioglitazone with insulin, the dose of insulin remains the same, or when the patient reports hypoglycemia, is lowered.
People older than 65 years do not require dosage adjustments yet the therapy must be started with the lowest dosage. The dosage should be very cautiously increased especially if the medication is taken along with insulin.
People with renal dysfunction with creatinine clearance more than 4 milliliters per minute, do not require dosage adjustments. The medication must not be taken by people on hemodialysis.
People with moderate to severe liver dysfunction should not use the medication.
Overdose signs and treatment
According to the clinical trials, the high doses up to 180 mg a day do not cause any serious or life-threatening adverse reactions. Still, if you overdosed and started feeling unwell, call your local poison help line or your physician and ask what you should do.
15 mg, 30mg
60 tabs, 120 Tabs