Carafate (Sucralfate 1 g)
Generic Carafate is not different from the branded medication based on Sucralfate except only by the name that is written on the box of pills and the price. Both medicines are used for prevention and treatment of stomach ulcer and duodenal ulcer, damaged gastrointestinal mucosa due to stress or intake of other meds, hyperacid gastritis, and in other conditions. They can be used even in children older than four years, pregnant women, and people with severe kidney failure who are on hemodialysis. Discover how to save on the therapy and use the medication safely from our full article.
What is the preparation you can buy as Carafate?
The brand name Carafate is registered and promoted by the pharmaceutical company Aptalis for the substance known worldwide as Sucralfate. This substance is also produced and marketed by other pharmaceutical companies and sold cheaper as they didn’t invest in the research and got the right to make it after the exclusive patent of the formula developer expired. These drugs can be found if when you need to buy Carafate you look for Generic Carafate instead.
The medication is an antiulcer, adsorbent, enveloping, antacid, gastroprotective agent used in various gastrointestinal tract conditions.
How does Sucralfate render its effect?
When in contact with the acidic environment of the stomach, the medication breaks down with the appearance of aluminum ions and the sulfate salt of sucrose. The aluminum ions provoke the denaturation of the protein structures of the mucus. The sucrose salt combines with denatured protein structures and provokes their fixation on the dead parts of ulcerative lesions (ulcers). Thanks to this, a film is formed that protects the mucous membranes from the effects of pepsin, acid, and bile components.
The components of the medication absorb the bile acids, substances produced by bacteria of the digestive tract, and thus lower the intensity of the local inflammatory process. The preparation almost does not affect the healthy tissues. The coverage of the affected areas after the dosage intake is maintained within six hours.
Sucralfate is absorbed in a small amount: only 5% of 5% disaccharide component and less than 0.02% aluminum. The metabolites are excreted in feces and an insignificant amount is washed out with urine.
Can you buy Generic Carafate to substitute the branded medication in your therapy?
If your healthcare provider appoints you the therapy with Carafate, you can buy Generic Carafate instead and here is why. First of all, the medications are identical. They differ only in the names indicated on their packages.
Nevertheless, the so-called generic version of the medication is substantially cheaper. The reason for that is that, first of all, the branded medication is vastly promoted and its makers set higher prices to get sufficient return investment. Secondly, other companies that make the same preparation didn’t develop the formula so they saved the money on research. They got the right to make the medicine using the data on its compound and precise formula only after the law allowed them to do so upon the exclusive patent expiration. Therefore, they do not need to set the higher price to cover the cost of research. And as they do not advertise their products, they also save a lot of money and are able to offer lower prices.
If you heard from someone that generics are inferior, you should not believe those rumors. First of all, all generics are approved and thoroughly tested for the compliance to the original formula before they become available on the pharmacies’ shelves. Secondly, the negative experience with generics can be explained by incorrect use of the medication. For instance, there are different dosages and formulations (i.e. tablets or mixture) of Sucralfate-based medications. When you buy Generic Sucralfate, to enjoy the same effect as from the branded drug that your doctor prescribed you, you need to make sure that you get the correct dosage of the active substance per pill and the formulation advised namely in your case. Besides, not to buy a placebo you need to opt only for reliable sellers with positive reviews and good reputation. Do not fall for the temptation to get the medication at the lowest price at a market from a questionable online pharmacy as most likely it is a placebo or an expired product that which will not match your expectations from this medical product.
When should you buy and start using Carafate?
The preparation is appointed for the prophylaxis and therapy of stomach ulcer and duodenal ulcer, prophylaxis and treatment of damaged gastrointestinal mucosa due to stress or intake of NSAIDs, hyperacid gastritis, gastroesophageal reflux disease, and hyperphosphatemia in patients with uremia who are on hemodialysis.
The medication is one of the numerous drugs used for the same or similar purposes. Therefore, even if you have a condition for which it is designed, make sure to consult a specialist whether it is reasonable for you to buy Sucralfate and use it in a pill form as sold at this webpage.
When shouldn’t you buy Carafate?
The preparation is prohibited to be used by people with hypersensitivity, dysphagia or obstruction of the digestive tract, bleeding from the gastrointestinal tract, severe renal failure, and in children aged younger than four years.
If there is no other safer alternative, pregnant women (if a doctor agrees) can order Carafate and start using it as it is considered relatively safe for gestating women and fetuses.
What are adverse effects of Carafate?
The use of the preparation can result in occurrence of dyspepsia, pain in the back, urticaria, skin rash, dizziness, diarrhea, dryness of the oral mucosa, itching of the skin, constipation, epigastric pain, headache, drowsiness, bloating, cramps, nausea, insomnia, and others.
Consult your physician to know how to act in case any of these or other adverse reactions occur.
How Generic Carafate interacts with other substances?
Antacids based on aluminum taken along with Carafate can become more toxic to the body especially for people with kidney dysfunction.
Histamine H2 receptors antagonists can lower the effectiveness of Sucralfate.
Vitamins A, D, E, and K as well as L-thyroxine have lower bioavailability (i.e. smaller amount is active within the body) when taken with Sucralfate.
The intake of the medication can interfere with the absorption of digoxin. It is advised to take digoxin at least two hours before Sucralfate-based drugs.
Theophylline, Ketoconazole, Norfloxacin, Ofloxacin, Ciprofloxacin, and Cimetidine’s absorption is also lowered by the use of any Sucralfate-based drugs.
The absorption of tetracycline antibiotics, Ranitidine, and Phenytoin is slowed down by Sucralfate.
Inform your therapist about all medications or supplements that you take when you plan to order Generic Carafate.
How to take Generic Carafate?
All formulations of the medication are intended to be taken orally. Regularly, the medication is prescribed to be taken four times a day –before every meal and right before bedtime. The single dosage is from 500 to 1000 mg (1 gram) of Sucralfate.
Alternatively, the medication can be prescribed to be used two times a day by one gram per intake.
It is not advised to take more than 8 grams of the medication a day.
Children older than four years are advised to be administered 500 mg four times a day if not recommended otherwise by a pediatrician.
The average duration of the treatment is 1-1.5 months. In rare cases it can be prolonged to 3 months.
Precautions when using Generic Carafate
If you suffer from kidney insufficiency, before you order Sucralfate, you should have an approval from your doctor to use the pills and be ready to frequently do tests to control the serum level of aluminum and phosphate. In the occurrence of sleepiness and seizures you must immediately inform your healthcare provider and stop taking the medication as these symptoms can indicate the toxic effect of aluminum.
When the medication is used along with antacids, they should be taken 30 minutes either prior or after Sucralfate intake.
The introduction of medication through a nasogastric tube can lead to the formation of bezoar (a foreign body found in the digestive system) with other drugs or solutions for parenteral nutrition (due to the ability to bind protein).
Overdose of Sucralfate
The appearance of unwanted reactions associated with taking high doses of the drug is unlikely. Long-term courses of therapy with high doses of the drug in patients with kidney pathologies can lead to toxic effects of aluminum on the body (seizures, severe asthenia). In this case, you must discontinue the therapy and inform your healthcare provider right away.