Cardura (Doxazosin 1 mg)
€39.70 – €273.10
Generic Cardura (Doxazosin) is a medication used for hypertension, congestive blood pressure and urinary retention associated with benign prostatic hyperplasia. The drug can be used as a single means for the conditions or in combination with other drugs including diuretics. The starting dosage of the drug is 1 mg per day in all conditions but it can be subsequently increased over 1-2 weeks of the therapy. Elderly patients and people with severe liver dysfunction need to use the drug cautiously starting with the lower dosage. You can find out more about the contraindications, special recommendations and dosage adjustments reading the medication guide below.
Brand name: Cardura
Generic name: Doxazosin
Indications: Arterial hypertension, High blood pressure, Benign prostatic hyperplasia
Analogs: Doxacard, Alfadil, Cardenalin, Cardular, Carduran, Diblocin, Normothen, Supressin
Generic Cardura (Doxazosin 1 mg) guide:
When should you use Generic Cardura?
You can buy Generic Cardura (Doxazosin) if your doctor prescribes you the brand-name drug for one of the following conditions:
– Hypertension (elevated blood pressure) – the drug is used as a part of combination therapy.
– Benign prostatic hyperplasia – the medication is used if urinary retention occurs due to the condition.
– Congestive heart failure.
How does Generic Cardura (Doxazosin) act?
The medication is a selective competitive blocker for postsynaptic alpha 1-adrenergic receptors (affinity for alpha-1 receptors is 600 times higher than for alpha-2), reduces systemic vascular resistance? prevents vasoconstriction caused by catecholamines, which ultimately leads to a decrease in blood pressure without the development of reflex tachycardia. Cardura (Doxazosin) reduces pre- and post-loading of the heart, contributes to the high-density lipoproteins/total cholesterol ratio increase, and reduces the total content of triglycerides and cholesterol.
Generic Doxazosin is effective in arterial hypertension including accompanied with metabolic disorders (obesity, hyperlipidemia, and decreased glucose tolerance).
In the long-term therapy, regression of the left ventricular hypertrophy, suppression of platelet aggregation, increased activity in the tissues of the activator of the profibrinolysin (plasminogen), and a decrease in the formation of collagen in the walls of the arteries are observed. The accumulated effect lowers the risk of ischemic heart disease development and increases the amount of angiotensin converting enzyme. In people with normal blood pressure, the drug doesn’t cause the blood pressure lowering. In people with hypertension, after a single intake the lowering of the blood pressure happens gradually. The maximum blood pressure lowering is observed in 2-6 hours. The hypotensive effect is maintained during 24 hours.
In people with benign prostatic hyperplasia, the medication improves the urodynamic parameters and reduces symptoms of the disease. The effect is related to the selective block of alpha 1-adrenergic receptors of the subtype Ia which makes 70% of all subtypes in the prostate that localize in the muscular stroma, prostatic capsule, in the neck of the bladder and in the proximal part of the urethra. The provided effect reduces the muscle tone of the prostate and makes it easier to urinate. The effect is observed in 66-71% of patients. It can be first observed in 1-2 weeks after the therapy start. The maximum effect is achieved after 14 weeks of the therapy and is later maintained for a long time.
How to use the drug?
Though the instruction provides general guidelines about the dosages, it is advisable to consult your doctor before you buy Generic Cardura (Doxazosin) and start using the drug.
The pills should be taken in the morning or before bed, preferably, on an empty stomach. Do not chew the pill, swallow it whole and wash down with a glass of water.
– Hypertension treatment dosages for adults with normal liver and kidney function: the starting dosage is 1 mg taken orally once a day. The optimal maintenance dosage is from 1 to 16 mg taken in a single intake. If the expected effect is not achieved, the dosage can be gradually increased with the interval of 1-2 weeks. For example, during the second week of the therapy the dosage can be increased to 2 mg a day, if still ineffective, after 2 weeks it can be increased to 4 mg a day, and so on. The maximum daily dosage of 16 mg is admissible only if the hypotensive effect is not achieved. Alternatively, other medications can be included such as thiazide diuretics, beta-adrenoblockers, calcium antagonists, angiotensin-converting-enzyme inhibitors in the therapy with the maintenance of the lower dosage of Doxazosin.
– For the treatment of benign prostatic hyperplasia the starting dosage is 1 mg a day. Of necessary, the dosage can be increased with the interval of 1-2 weeks up to 2-4 mg a day – a recommended maintenance dosage. The maximum daily dosage is 8 mg a day.
– For the therapy in elderly patients, the starting dosage for any condition is 0.5 mg a day.
– People with impaired liver function should take the medication cautiously, i.e. in the lowest dosages.
Whom the drug is contraindicated?
You should not buy Generic Cardura (Doxazosin) and use the drug if you are pregnant, breastfeeding, have allergy to one or several ingredients of the medication, suffer from mitral and aortic stenosis or orthostatic hypotension.
The drug is also not advised for children below 18 years of age and people with severe liver function impairment.
What side effects can Cardura (Doxazosin) cause?
After the first medication intake, some people experience the following adverse reactions: hypotension, dizziness, fainting, swelling, tachycardia, sleep cycle violation, fatigue, shortness of breath, headache, nervousness, irritability, abnormal drowsiness, blurred vision, rhinitis, dryness in the mouth, abdominal discomfort, nausea, constipation, chest pain, cerebral circulation disorder, and incontinence.
If you have these or other unpleasant symptoms after the first medication use, inform your doctor about them and follow his or her recommendations on the adverse effects relief.
With what medications the drug should not be combined?
Generic Cardura (Doxazosin) enhances the hypotensive effect of other medications used to treat blood pressure.
Estrogens that promote liquids retention in the body contribute to the increase in the blood pressure.
Nonsteroidal anti-inflammatory medications lower the effect of Doxazosin.
Doxazosin lowers the effect of metamninol and ephedrine what can lead to severe arterial hypotension and tachycardia.
When used with alcohol, the probability and severity of adverse effects increases.
What should you do in the overdose with Cardura (Doxazosin)?
The symptoms of the overdose are hypotension which commonly manifests in dizziness, fatigue, and fainting.
The first measure is to lie down keeping the head in line with the body. If in 10-15 minutes the condition isn’t improved, it is important to seek medical assistance. Doctors will administer you vasopressor drugs (medications to narrow blood vessels) and take other measures if necessary to relieve the symptoms.
Is there a difference between the brand-name drug and the generic?
If your doctor prescribes you Cardura, you can buy Generic Cardura (Doxazosin) without any doubts as the drugs are identical. Generics are cheaper because they are made by other pharmaceutical companies who are able to find ways to minimize their operational expenses. However, you have to make sure that you purchase the right dosage of the generic as the drug comes in different doses per pill
1mg, 2 mg, 4 mg
20 pills, 40 pills, 60 Pills, 80 pills, 160 Pills