Description

Generic Casodex (Bicalutamide 50 mg) guide:

What is the medication called Casodex?

The history of the active substance used in this branded medication dates back to 1967 when it was synthesized as a result of modification of another substance and then it was believed that its main property was the bacteriostatic effect. However, many years of research had proven its efficacy in certain types of cancer. For the first time for the therapy of prostate cancer, the medication called Casodex was used in 1995. Currently, it is also produced by other drug-making companies but under other names. You can get the same medication but at a lower price if when you are appointed Casodex you buy Generic Casodex instead (i.e. the same drug but made by another company).
Bicalutamide is a substance with the non-steroidal antiandrogenic activity. It does not influence any other endocrine processes. Bicalutamide connects to androgen receptors and inhibits the effect of androgens. This causes the regression of malignant tumors in the prostate.

After the pill is taken by mouth, it is promptly seized from the stomach and food doesn’t influence its activity. In the daily intake of the Casodex pills, the level of the active substance in plasma raises nearly ten times due to a long half-life, which makes it feasible to take the drug 1 time per day. The pharmacokinetics of the medication is not influenced by age, renal dysfunction, and mild or moderate hepatic impairment. However, in men with severe liver dysfunction, the elimination of the medication from the plasma is slowed.

The preparation is well bound to the blood plasma, around 96%. It is metabolized in the liver. The metabolites of the medication are excreted in urine and bile nearly in equal proportions.

What is Generic Casodex? Is it inferior to the branded medication?

Bicalutamide, the active ingredient of Casodex, is manufactured and marketed by numerous pharmaceutical companies because it is no longer protected by the know-how of the inventor. Although the other companies cannot use the same name to trade their medication and are obliged to come up with the different names. For instance, Bical, Bicamide, Binabic, Bypro, Apo-Bicalutamide, Bicalutamide Accord, and so on are all the same medications. You don’t need to remember these names as you can ask pharmacists for Generic Casodex or Bicalutamide and they will know what medication you need. Besides, it is quite easy to find the medication online. For instance, you may have come to this webpage looking for a way to buy Casodex and here we offer you the same medication but cheaper, i.e. its generic version.

You should not worry about the quality and effectiveness of the generic medication as long as you purchase it from a reliable seller with good reviews. The medications approved as generics all underwent thorough testing and were approved only if they comply with the original formula and the claimed effect. They are cheaper because they are mostly manufactured in the developing countries where the production costs are cheaper. Besides, it’s no secret that the branded medications are quite overpriced especially in the countries such as the U.S. But of course, if you fall for the lowest price at the online pharmacy with no reviews, you can run into placebo or an inferior medication.

When it is time to buy Generic Casodex?

The medication is used for the therapy of prostate cancer if certain conditions are present. It means that if you are diagnosed with the condition you don’t need to buy Bicalutamide right away if your oncologist doesn’t say you to do so. You need to consult your doctor and ask him or her why you aren’t prescribed this medication if you wish to buy it to be sure that it is suitable and safe for you.

Please keep in mind that cancer is a life-threatening condition that must not be self-diagnosed or treated. It requires a comprehensive medical examination in case of any suspicion of cancer, then, a full-fledged treatment including surgery, chemotherapy, and so on as indicated by your oncologist. It is not enough to use Casodex pills to suppress the disease.

Casodex of Bicalutamide pills are prescribed for the treatment of spread prostate cancer along with an gonadotropin-releasing hormone or surgical removal of testicles; locally spread prostate cancer as a monotherapy (only this medication used) or adjuvant therapy (i.e. addition to the main therapy) along with surgical removal of all or part of the prostate gland or radiotherapy; and in locally spread non-metastatic prostate cancer in cases when surgical castration or other medical interventions are not applicable.

When must not you use Casodex?

The preparation is contraindicated to be used in the therapy of women and children, for men who are allergic to the main or additional substances from the pills, in simultaneous use of terfenadine, astemizole and cisapride, in case of lactose intolerance, lactase deficiency or malabsorption of glucose-galactose.
Additionally, the pills should be cautiously used in any liver diseases.
If you are not sure about any of these conditions or have any other chronic or acute conditions when you plan to buy Generic Bicalutamide and start the therapy, make sure to inform your doctor about them.

Generic Casodex adverse effects

The adverse reactions from the generic use are the same as from the use of the branded pills and can include breast augmentation in with hypertrophy of glands and adipose tissue, painful sensations in breasts, flushes of blood to the face, lowered sex drive, erectile dysfunction; diarrhea, nausea, raise of liver transaminase, cholestasis and yellowing of the skin, itching, asthenia; alopecia, elevation of the body mass; hypersensitivity reactions, including angioedema and hives, and others.

Before you order Casodex and start taking the pills, consult your oncologist in case of which adverse effects you should inform him or her right away and which of them are normal and you can continue using the pills.

With what medications you must not combine Casodex pills use?

The medication is prohibited to be used with terfenadine, astemizole, cisapride, and therefore must not be used with these medicines at all.

The medication should be cautiously used at the same time with cyclosporine or calcium channel blockers. It may be required to lower the dose of these meds. If you combine the medications, it is advised to check the concentration of cyclosporin in the plasma and the general condition regularly.

The concurrent use of Bicalutamide and preparations that suppress microsomal oxidation of meds in the liver, for example cimetidine or ketoconazole, can cause an elevation of the Bicalutamide level in the in plasma and, possibly, raised likelihood of negative reactions.

The preparation enhances the effect of coumarin anticoagulants, including warfarin.

How to use the pills?

The medication is taken orally regardless of meals.

In spread prostate cancer the medication is used along with gonadotropin-releasing hormone or surgical removal of testicles in the dosage of 50 mg once daily. The use of the pills should be initiated at the same time the therapy with gonadotropin-releasing hormone is started or right after or surgical castration.

In locally spread prostate cancer the daily dosage is 150 mg. The preparation should be taken for a long period of time, at least for two years.

If signs of disease development occur, the therapy must be discontinued.

Taking into account that the metabolism of the preparation can be slowed down in the patients with violated liver function, it is advised to monitor your liver function in case you suffer from any liver conditions and use the pills. In case the medication contributed to the development of severe changes in liver function, the therapy must be discontinued.

If Bicalutamide is used by men who also receive anticoagulants of the coumarin group, their doctors should inform them that they need to regularly monitor prothrombin time.