Catapres (Clonidine 100 mcg)
€59.10 – €134.20
The brand name drug called Catapres is based on the ingredient called Clonidine and is marketed under a variety of trade names. It is used mainly for the blood pressure control but is also prescribed in alcohol or opiates abstinence, attention deficit hyperactivity disorder, migraines, and other conditions. The drug can be used in children aged 6 or more for ADHD and in adults for other conditions but cannot be used in pregnant women. Catapres should be cautiously used, and sometimes in reduced dosages, in elderly patients and people with severe liver dysfunction. The generally recommended starting and maintenance dosages, as well as dosage adjustments, contraindications, precautions, measures in the overdose, etc. are listed in the medication guide below.
Brand name: Catapres
Generic name: Clonidine
Indications: High blood pressure, Hypertensive crisis, Open-angle glaucoma, Alcohol withdrawal syndrome, Opioid withdrawal syndrome
Analogs: Arkamin, Adesipress, Catapresan, Catarpres, Catarpresan, Chlornidinum, Clonidinhydrochlorid, Clonidinum, Clonistada, Dixarit, Duraclon, Duraclont, Ipotensium, Isoglaucon, Tenso-Timelets
Generic Catapres (Clonidine 100 mcg) guide:
Generic Catapres (Clonidine) is a drug prescribed primarily for the treatment of hypertension but is also used for other conditions such as withdrawal syndromes, migraines, and others.
The medication was first synthesized in the 1960s and was designed to be used as a nasal medication to cope with stuffy nose as it has an adreno-stimulating effect and the ability to cause spasms in the capillaries of the nasal mucosa.
When should the drug be used?
You can buy Generic Catapres if your doctor prescribes you Catapres, Kapvay, Nexiclon, Clophelin or other medication that has Clonidine as an active substance. The drug is used to lower blood pressure in hypertension, for some cases of anxiety disorders, withdrawal syndromes including resulting from smoking or alcohol dependence, migraines, pain disorders, and flushes associated with menopause.
What is the mechanism of action of Catapres (Clonidine)?
The main mechanism of the medication is due to the stimulation of postsynaptic alpha 2-adrenoceptors in the vasomotor center of the medulla oblongata and subsequent gradual reduction of the flow of the entire sympathetic impulses to the heart and blood vessels in the presynaptic level.
The drug also reduces the secretion of catecholamines. The hypotensive effect provided by the drug is accompanied by the decline in cardiac output and the decrease in systemic vascular resistance, including kidney vessels. Clonidine also causes the intraocular pressure lowering associated with a decrease in the secretion and outflow of aqueous humor. Through the influence on the central nervous system, the drug has an analgesic effect.
In the fast intravenous injection, before the hypotensive effect, a short increase in the blood pressure can occur due to the excitation of vascular alpha 1-adrenoceptors. This is the cause the intravenous use of the drug is restricted. It cannot be used in elderly patients as there is a high risk of myocardial infarction or heart attack.
In the oral drug intake, the hypotensive effect occurs within 1-2 hours and lasts for 6-8 hours.
One of the outstanding properties of Clonidine is its ability to relieve somatovegetative manifestations of opioid and alcohol abstinence: it eliminates fear, cardiovascular disturbances, and other symptoms. The scientists believe that these effects are due to the decrease in the central adrenergic activity that occurs when Clonidine excitates the alpha 2-adrenoreceptors of inhibitory neurons. The medication also provides a sedative and sleeping pill effect as well as lowering of the body temperature.
How to use the drug?
Before you buy Generic Catapres, we advise you to consult your doctor first as the generally recommended dosages provided in the instruction may not be suitable for you.
The pills are taken two times a day – in the morning and before bedtime with or without food. You need to swallow the pill without chewing and wash it down with sufficient amount of water.
– Hypertension treatment with any medication in which Clonidine is the active substance is started with 0.1 mg two times a day with sufficient interval. The regular maintenance dosage is 0.2-0.6 mg taken divided into two intakes. The increase of the dosage should be made gradually. For example, you can increase the intake dosage to 0.4 during the second treatment week, and then to 0.6 mg after 1-2 weeks if the effect is insufficient but only if you tolerate the drug well. The maximum daily dosage is 2.4 mg (1.2 mg taken 2 times a day).
– Attention deficit hyperactivity disorder in children older than 6 years is started with the daily dosage of 0.1 mg before sleep. The dosages can be gradually increased by 0.1 mg a day under a doctor’s supervision. The increased dosages are divided into two intakes. The maximum dosage for children is 0.4 mg taken in two intakes.
– As a pain relief drug, Catapres is used only in the hospital in a form of epidural anesthesia.
– Patients of advanced age and those with impaired liver function are advised to start the therapy with the lower dosages.
Whom the drag is contraindicated?
Do not buy Generic Catapres (Clonidine) if you are allergic to its ingredients, are pregnant or breastfeeding, suffer from depressive conditions or conditions that influence the cerebral vessels, heavy degree of occurrence of atrio-ventricular blocks, are prone to bradyarrhythmia, after a myocardial infarction, severe liver failure, obliterating diseases of peripheral vessels.
If you are not sure whether you have some of the conditions in which the medication should not be used, make sure to discuss your symptoms and diagnoses with your doctor as well as undergo necessary tests.
What adverse reactions can Catapres (Clonidine) cause?
In some people the medication can cause a variety of adverse reactions such as violation of heart rhythm, somnolence, fatigue, mood changes, depression, dizziness, headache, rash, itching, swelling of the limbs, and others.
If you experience any of these symptoms after the first use of the drug yet they are mildly pronounced, you can continue using the drug. If the side effects do not fade over 2-3 days or even get worse, consult your doctor.
If the side effects start to manifest as you increase the dosage, you should also consult your doctor and possibly reduce the dosage or ask your doctor to replace the medication with another drug with the similar effect but with another active substance.
With what medications the drug should not be combined?
People, who use the medication along with beta blockers, can experience sharp increase in the blood pressure upon withdrawal of Clonidine.
In the combination of the drug with birth control pills, the sedative action of Clonidine can be increased.
When combined with tricyclic antidepressants, the hypotensive effect can be lowered.
The drug can also amplify or extend the effect of Vecuronium.
If you are unsure whether the drugs or supplements you use are compatible with Generic Catapres (Clonidine), make sure to consult your doctor before you buy the medication and start the therapy.
What should you do in the overdose with Catapres (Clonidine)?
If you overdose with Catapres or its analogs, you can experience the symptoms typical for hypotension such as dizziness, fatigue, fainting, heart rhythm violation, and others.
The treatment is symptomatic and should be made by a doctor in a hospital as it may require intravenous infusions of vasoconstrictive drugs, and so on.
Is there a difference between the brand-name drug and the generic?
Generic medications are made under a license if the original drug developer sells the right to make the same drugs to the other pharmaceutical companies or is obliged to give the chemical formula to other drug makers if the drug is classified an essential medication.
In case with Clonidine, it is quite an old medication and the exclusive patent of the original developer expired long ago. Currently, the same medication is manufactured by thousands of pharmaceutical companies around the world. All of them use the same formula, ingredients, and are obliged to indicate the active substance name under the trade name. All of these drugs have the same effect and have been properly tested before they are allowed onto the market. Some of the drug makers sell the drug cheaper, some more expensive but there is no point of paying more money for the same drug.
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