Coreg (Carvedilol 6.25 mg)
€39.00 – €91.80
Generic Coreg (Carvedilol) is a drug used for hypertension, congestive heart failure and other heart-related conditions. The medication is an alpha- and beta-blocker without intrinsic sympathomimetic activity. It is different from the majority of the medications used for hypertension treatment; therefore, it can cause other side effects and requires gradual dosage increase in case the minimum dosage is insufficient.
Brand name: Coreg
Generic name: Carvedilol
Indications: Arterial hypertension treatment, Chronic stable angina, Congestive heart failure
Analogs: Cacra, Cakra, Cardiwas, Carloc, Carvedilolum
Generic Coreg (Carvedilol 6.25 mg) guide:
When should the drug be used?
You can buy Generic Coreg (Carvedilol) if your doctor appoints you the therapy with Coreg or other medication with the active ingredient Carvedilol. However when you buy the drug online, make sure to check that you choose the right dose of the active substance per pill.
The conditions in which the medication is used include:
– Congestive heart failure;
– After a heart attack;
– Left ventricular dysfunction.
How does Coreg (Carvedilol) act, what is its principle of action?
The medication is an alpha- and beta-blocker without intrinsic sympathomimetic activity. It blocks alfa-1, beta-1 and beta-2 adrenergic receptors, exerts vasodilating (blood vessels widening), antianginal and antiarrhythmic action.
The vasodilating effect is primarily related to the blockage of alfa-1 adrenergic receptors. Though the blood vessels expansion, the systemic vascular resistance is lowered. The drug also slows down the vessels narrowing neurohumoral activation in the vessels and the heart. It has a expressed vascular expanding effect and relieves afterload on the heart. Carvedilol also reduces plasma renin activity. It does not have sympathomimetic activity, though has membrane stabilizing properties, inhibits proliferation and migration of smooth muscle cells, affecting specific mitogenic receptors. It doesn’t provide effect on the lipid metabolism and maintenance potassium, sodium, and magnesium in the plasma.
Unlike beta-blockers, the medication doesn’t increase systemic vascular resistance nor decreases peripheral blood flow. Heart rate decreases slightly. In patients with coronary heart disease, it exerts an antianginal effects.
The medication also has an antioxidant effect, reduces the risk of death in people with congestive heart failure by 65% and the frequency of need of urgent medical assistance by 38%.
How to use the drug?
If you don’t have direct indications how to use the medication, you can buy Generic Coreg (Carvedilol) and use it as said in the instruction but we still highly recommend you to consult your doctor first.
The pills are taken with food to reduce the likelihood of side effects related to digestive tract and make the medication effect not instant, i.e. to allow the action develop gradually during the day. The pills should be taken with sufficient amount of water, swallowed entirely without chewing.
– For hypertension treatment in adults, the starting dosage is 6.25 mg taken 2 times a day. If the effect is insufficient and you don’t have any side effects using the drug, the dosage can be increased to 12.5 mg taken twice a day after 1-2 weeks in the therapy. Subsequently, the dosage can be increased up to 25 mg taken twice a day. The maximum daily dosage is 50 mg taken 2 times a day.
– For congestive heart failure treatment in adults, the starting dosage is 3.125 mg taken 2 times a day. If the dosage doesn’t cause any side effects but the medication effect is not sufficient, two weeks into the therapy the dosage can be increased to 6.25 mg a day taken 2 times a day. Subsequently, the dosage can be increased in two weeks to 12.5 mg 2 times a day, and even 25 mg twice a day. All increases in the daily dose should be made not sooner than 2 weeks after the previous dosage increase. The maximum daily dosage for people with the body mass under 85 kg is 50 mg divided into two intakes, for people with the body mass over 85 kg 100 mg divided into two intakes.
– For left ventricular dysfunction treatment in adults, the starting dosage is 6.25 mg taken 2 times a day. If the dosage doesn’t cause any side effects but the medication effect is not sufficient, 3-10 days into the therapy the dosage can be increased to 12.5 mg a day taken 2 times a day. Subsequently, the dosage can be increased in two weeks to 25 mg twice a day but not sooner than 3-10 days of the intake of the previously increased dosage.
In general, people with kidney dysfunction do not need dosage reduction but they should do regular tests using the drug and especially after the dosage increase.
The drug is allowed to be taken by people with mild to moderate liver impairments but is contraindicated in severe cases.
The use of medication during pregnancy and breastfeeding
It is possible to use Generic Coreg (Carvedilol) if the expected benefits will outweigh the risk to the baby.
If during lactation the woman needs the drug use, she should take a break in breastfeeding for the duration of therapy.
Whom the drug is contraindicated?
You should not buy Generic Coreg (Carvedilol) and use it if you are allergic to the drug’s components, suffer from constantly lowered blood pressure, in some cases of congestive heart failure; bradycardia, heart block, sinoatrial block, sick sinus syndrome, cardiogenic shock, obstructive pulmonary disease with, asthma, or severe liver dysfunction.
The medication should be cautiously used under a doctor’s supervision in vasospastic angina, recent aggravation of the heart failure, disorder of the peripheral vessels, diabetes, hypoglycemia, pheochromocytoma, hyperthyroidism, psoriasis, renal impairment, elderly age. The drug is also contraindicated for children.
If you are unsure whether the conditions you have are included in one of the categories, consult your doctor.
What side effects can Coreg (Carvedilol) cause?
The side effects that can be caused by Carvedilol are similar to those of other drugs used for the same conditions: dizziness, headache, hypotension, fatigue, muscle weakness, insomnia, dryness of mouth, indigestion, nausea, pain in the chest, nasal congestion, shortness of breath, allergic skin reactions, swelling, and others.
If you have any of these side effects or others, contact your doctor and ask how you can minimize them or should you replace the drug with another one or not.
With what medications the drug should not be combined?
The medication enhances the effect of other medications used to lower blood pressure.
Combined with insulin and hypoglycemic medications it can enhance their hypoglycemic action and cause the occurrence of tachycardia, and other symptoms typical for the condition.
Carvedilol combined with cardiac glycosides, diuretics, and/or other medications from the same class can slow down the atrioventricular conduction.
It increases the concentration of Digoxin in the blood serum.
General anesthetics enhance the negative effects of the medication.
Phenobarbital, Rifampicin and other agents that inhibit microsomal enzymes, accelerate the drug metabolism and reduce its concentration in the blood plasma.
Generic Coreg (Carvedilol) should be cautiously used along with antiarrhythmic medications.
If you use any other medications or additives not listed here, make sure to inform your doctor about them anyway as he or she may consider that they are incompatible with Coreg.
What should you do in the overdose with Coreg (Carvedilol)?
The symptoms of the overdose include expressed hypotension, bradycardia, heart failure, cardiogenic shock, cardiac arrest, shortness of breath, bronchospasm, vomiting, fainting, confusion, or generalized convulsions.
If you accidentally overdosed, seek immediate medical assistance. The treatment should be made in the hospital and requires constant doctor’s supervision as well as measures to elevate blood pressure.
The first measures before the ambulance arrives are: induce vomiting during the first few hours after the overdose then lie down with the legs up.
Is there a difference between the brand-name drug and the generic?
Cheap generic versions of the drug are no different from the brand-name drug. Therefore, there is no need to spend more money on the pills. It is possible because Carvedilol isn’t made by a single pharmaceutical company but rather by hundreds of different companies located in different countries of the world. Obviously, they have varying operational costs and policies and are able to set greatly different prices for the same drugs. As for the quality control, all generics are checked for the compliance with the original drug formula and ingredients before they are approved.
6.25 mg, 12.5 mg, 25 mg
90 pills, 180 Pills