Description

Deltasone is one of the denominations used for the medication included in the List of WHO Essential Medicines as Prednisolone. You may wonder why a single drug has two names. In fact, it has many other names. One name, Prednisolone, is a name used internationally and is the name of the active substance. However, sometimes it can be used also as a trade name. Other names arise from the wish of different drug makers to make their medicines distinguishable on the market. They make the same medicine but register a commercial name for it which can be used by this company only. Sometimes some of these medications are greatly cheaper than other even though they have the same compound and render the same effect. You can buy Deltasone if you look for Generic Deltasone and get the same medicine but under a different name much cheaper.

Prednisolone is an anti-inflammatory, antihistamine (against allergy), immunosuppressive, anti-shock, and glucocorticoid medication used in a variety of conditions about which you can find more info in the following section of this article.

When must Deltasone (Prednisolone) be used?

Due to a wide range of the medication’s actions, it is used in a wide variety of medical conditions in different formulations, i.e. for some conditions are needed injections, for others – intravenous infusions, and the simplest way to use the medicine which is suitable in some illnesses is oral tablets intake.

On this webpage we sell namely Prednisolone pills that can be used conveniently at home for such conditions as systemic diseases of the connective tissue, for instance, rheumatism; rheumatoid arthritis; dermatomyositis; nodular periarteritis; scleroderma; bronchial asthma, asthmatic status; acute and chronic allergies; Addison’s disease, acute adrenocortical insufficiency, adrenogenital syndrome; hepatitis, hypoglycemic conditions, agranulocytosis, leukemia, lymphogranulomatosis, purpura, hemolytic anemia; chorea; eczema, pruritus, exfoliative dermatitis, psoriasis, seborrheic dermatitis, systemic lupus erythematosus, erythroderma, alopecia, and many others.
The dosages, treatment course durations, and methods of the medication administration greatly vary. Therefore, before you buy Generic Deltasone, you need to find out your precise diagnosis from your doctor and receive direct instructions on how to use this medicine in case you need it.

How is the effect of Deltasone achieved?

The effects of the medication are implemented through the stabilization of cell membranes, inhibition of accumulation of macrophages, a decrease in migration of leukocytes, a decrease in the permeability of capillaries, and prevention the formation of swelling. It suppresses phagocytosis (the uptake of the pathogens by the body cells), affects the metabolism of arachidonic acid, as well as the synthesis and release of inflammatory mediators. The immunosuppressive effect of the medication is due to inhibition of T- and B-lymphocyte activity, and also a suppression of the release and impact of interleukin-2.

The medication renders a catabolic action and elevates the level of glucose in the blood. It exhibits some mineralocorticoid activity, i.e. increases the reabsorption in the renal tubules of sodium, and enhances the excretion of potassium and calcium from the body, especially with an increase in their level in the plasma.

Deltasone is quickly absorbed from the gastrointestinal tract and penetrates the blood in a quite high amount, i.e. has a high bioavailability. The maximum level of it in the blood is observed within one to one and a half hours after the dosage intake. Deltasone is metabolized in the liver, kidneys, small intestine, and bronchi. It is excreted through kidneys in the form of metabolites, i.e. simpler substances and around twenty percent is excreted in an unchanged form.

Can you replace the branded drug with Generic Prednisolone?

Considering that the original formula for the medication currently marketed as Deltasone was developed back in 1955, it’s not surprising that numerous pharmaceutical companies around the world have the possibility to make the same medicine. It happens when an exclusive patent expires or when the World Health Organization decides that it is an essential medicine which formula must be shared with the generics makers before the patent expired in order to balance the accessibility of new and effective medications for all people regardless of their incomes. In this case, the medication is included in the List of Essential Medicines (EML). In case of Prednisolone, both of these conditions are met – the drug was developed more than half than a century ago and it is included in the EML. Therefore, you can safely buy Prednisolone made by any manufacturer who is licensed to make it (you can find this out easily – if the drug is available at the drugstores, it is licensed).

Do not be turned off by the low prices of generics. They do not mean that these drugs are inferior but only that their manufacturers do not invest in advertising and promotion unlike the manufacturers of the branded medicines such as Deltasone. It is only reasonable to pay for the effectiveness only and not for the name on the box of pills.

When is Prednisolone contraindicated to be used?

You must not buy Generic Prednisolone and use it in case you have any of the below-listed conditions as its use can greatly harm your health:
– Gastric and duodenal ulcer;
– Osteoporosis;
– Cushing’s syndrome;
– Proneness to thromboembolism;
– Renal failure;
– Severe arterial hypertension;
– Systemic mycoses;
– Viral infections;
– Parasitic diseases;
– Vaccination period;
– Active form of tuberculosis;
– Glaucoma;
– Thrombophlebitis;
– Poliomyelitis;
– Mental illnesses;
– Hypersensitivity to Prednisolone.

Besides, the medication must not be used in the violated metabolism of arachidonic acid, which can clinically manifest itself as an asthmatic triad.

The medication can be used during pregnancy if the expected benefit is greater than the anticipated risk.

What are possible negative effects caused by Deltasone use?

Before you order Deltasone, you should be ready that the medication use can cause certain negative effects on your body such as an increase in body weight, a decrease in the rate of growth, hyperglycemia up to the development of steroid diabetes, dysfunction of the adrenal cortex, increased acidity of gastric juice, ulceration of the digestive tract, an increase in the excretion of potassium, sodium retention in the body with the formation of edema, a negative nitrogen balance, arterial hypertension, allergic reactions, and others.

Based on your existing conditions, your doctor should assess the risks of Prednisolone use, consult you about the most likely side effects that you can develop and tell you how to cope with them.

With what medicines you must not combine this medication?

Generic Deltasone or Prednisolone can negatively interact with certain medications, for instance, salicylates, anticoagulants, diuretics, hypoglycemic drugs, cardiac glycosides, Rifampicin, antihypertensive drugs, and others. Therefore, before you order Generic Deltasone, if you already take any medications, you must carefully read the instruction and if a medication you use is contraindicated to be combined with it, look for an alternative or ask your doctor.

How to use Generic Deltasone?

Preferably, the dosage should be established individually for every patient. Your doctor should also instruct you when to use the pills in your case as usually two-thirds or the whole are taken in the morning.
For the treatment of acute conditions in adults as a substitution therapy, the drug is prescribed in a dose of 20-30 mg per day with a gradual transition to a maintenance dose of 5-10 mg. Depending on the severity of the condition treated, the initial dosage can be from 15 to 100 mg a day and the maintenance dose in a range between 5 to 15 mg a day.

For the treatment of acute conditions in children, the initial dosage is 1-2 mg per kilogram of the body mass and split into four or six intakes. The maintenance dose is 300-600 mcg per kilogram of the body weight a day.
The pills should be taken orally without chewing or crushing and wash down with sufficient amount of water. The therapy must not be stopped abruptly but with the gradual reductions of the daily doses.

What happens if you overdose?

The risk of an overdose increases in the long-term use of Deltasone especially in high doses. The symptoms of an overdose are the elevation of the arterial pressure, swelling, and enhancement of the side effects.

The treatment of an acute overdose includes immediate gastric lavage or induction of vomiting.

Chronic overdose is treated with the gradual lowering of the daily dose.