Demadex (Torsemide 10 mg)
€39.10 – €162.65
Demadex is a brand of the medication also known as Torsemide. It is a loop diuretic (water pill) used for a variety of conditions such as arterial hypertension or elevated blood pressure, swelling associated with heart failure, and in kidney failure. Although the same substance is used for these conditions, the dosages greatly differ. You can find out what doses are used for each condition in particular from our complete article on the drug. In the article, you can also find the list of contraindications and precautions that should be followed when you use Demadex or a generic version of the medication.
Brand name: Demadex
Generic name: Torsemide
Indications: Arterial hypertension (high blood pressure), Heart failure, Swelling (edema), Kidney failure
Benefits: Washes out extra water from the body reducing swelling and lowering the arterial pressure
Analogs: Luprac, Torasemida, Torasemidum, Demadax, Dytor
Generic Demadex (Torsemide 10 mg) guide:
What is the medication sold under the trade name Demadex?
The drug available under the trade name Demadex is, as well, sold under other names. It is based on the main ingredient Torsemide and is a diuretic medication used for arterial hypertension, swelling associated with heart diseases, and so on.
The medication sold as Demadex as well as under other names if you look for Generic Demadex is a loop diuretic that has a diuretic, saluretic (enhancing the elimination of sodium, potassium, and other elements), and some antihypertensive action. The medication intensifies diuresis and thus has a pronounced anti-edematous effect. You can be appointed to buy Demadex if you suffer from swelling associated with heart failure or elevated blood pressure accompanied by swelling.
After the oral intake of the pills, the effect of the medication develops within two-three hours. After you take the pill, the active substance of the preparation is well absorbed from the gastrointestinal tract and the peak concentration of the medication in the blood plasma is observed within one-two hours after the prescribed dosage intake.
The medication is characterized by a high degree of association with the plasma protein (about 99%) and the bioavailability of about 80-90%. In the body, Torsemide is metabolized with the formation of pharmacologically inactive metabolites and metabolites that have weak pharmacological activity. The medication is excreted in urine in an unchanged form and in form of metabolites. The drug is washed out of the body within three-four hours. When the renal function is impaired, the half-life of Torsemide does not change. If the liver function is impaired, it insignificantly changes the half-life of the drug. Torsemide is not cumulated in the body and is not excreted by hemodialysis and hemofiltration.
Can you buy Generic Demadex when your doctor tells you to buy branded Demadex?
You can without any doubts buy Generic Demadex instead of the branded medication upon condition that you find a reliable drugstore that sells the best-quality generic medications and is willing to provide you all necessary information such as the name of the active substance of the medication, the manufacturer name, and the dosage per pill. All of these aspects are very important because there are different diuretics used in different conditions. Besides, the same medication can be prescribed in different dosages for different conditions.
Our online pharmacy guarantees that when you purchase the generic medication from our range of products, you receive the drug identical to the branded one in quality and effect. The lower price of the products does not indicate their lower quality but the fact that they are less advertised than the branded ones and are made not by the inventor of the medication but other pharmaceutical concerns that got the right to make the same medications after the patent of the inventor expired. All medications that we sell correspond to all international quality and safety standards. They are accompanied by all necessary certificates. Moreover, the production and selling of generics are even promoted and controlled by the World Health Organization with the aim to ensure that all people regardless of their income level receive the most innovative and effective treatment.
Currently, we offer you the generic of Demadex made by the world-known pharmaceutical company Cipla in the dosages of 10, 20, and 40 mg. Make sure to order the dosage per pill prescribed by your doctor to avoid the need to split the pills manually or accidental overdosing.
When Generic Demadex is used?
The medication is used for different conditions but also in different dosages. You can be appointed to buy Torsemide 2.5 mg or 5 mg pills for the therapy of arterial hypertension.
The preparation in the dosages of 5 mg, 10 mg or 20 mg is used for the elimination of swelling associated with heart failure.
The dosages of 50 mg, 100 mg, or 200 mg are used for the treatment of people with severe kidney insufficiency with creatinine clearance less than 20 milliliters per minute accompanied by swelling and arterial hypertension.
Please note that even if you have one of the conditions listed here, it is still highly advised to consult a doctor about the possibility of Torsemide use before you purchase the medication.
In what conditions the medication must not be used?
The preparation is contraindicated to be used in people with hypersensitivity to the drug and any sulfonylurea derivatives. The pills also contain lactose which is why it is contraindicated to be used by people with malabsorption of glucose-galactose, galactosemia and lactase deficiency.
You should not buy Generic Torsemide if you suffer from arterial hypotension, impaired renal function, which is accompanied by anuria (inability to urinate), as well as hepatic coma and state predeceasing coma.
The drug is not prescribed for people with water-electrolyte imbalance (Torsemide administration is possible only after correction of the water-electrolyte balance).
The drug is not used in pediatrics, as well as for the therapy of pregnant and lactating women.
Caution should be observed in the appointment of Torsemide to patients with arrhythmia, diabetes mellitus, severely impaired liver function and prostatic hyperplasia and other conditions that can cause urination problems, as well as patients at risk of hyperuricemia and gout.
For patients over the age of 65, Torsemide is prescribed only under the strict supervision of the attending physician.
Persons whose work is related to the management of potentially dangerous mechanisms and driving a car should take caution with the preparation of Torsemide.
How to take Generic Torsemide pills?
The medication is intended for oral use. The pills can be split to get the right dosage if you have higher dose pills that you need per intake but you should not chew or crush them. To enjoy the maximum effect, it is advised to take the pills in the morning during the meal. The daily dose of the medication is usually taken in a single intake. The duration of the drug use and the required dose is determined by the attending physician. If you hadn’t consulted your doctor yet and plan to order Demadex, please make sure to clarify with him or her whether the medication is suitable for you and how should you take the tablets. Here we provide the general recommendations from the official instruction for information only.
People with essential hypertension usually are prescribed to take 2.5 mg a day. If after two months of use of the medication the control over the arterial pressure is still insufficient, the dosage can be increased to 5 mg a day. The dosages over 5 mg a day are not used for this condition.
People who suffer from swelling are advised to use the drug in the dosage of 5 mg a day. If the effect is insufficient, the dosage can be elevated to 20 mg a day.
People with chronic kidney failure are recommended to take 20 mg a day and if the dosage is insufficient, it can be elevated up to 200 mg a day gradually. However, you should not aim for 200 mg a day; the optimal dosage is the minimum effective one.
In the need of long-term use of Torsemide, the level of electrolytes, lipids, glucose, creatinine and uric acid in the blood plasma should be regularly monitored.
What drugs and substances can affect Demadex’s effect?
Before you order Generic Demadex, make sure to check with your physician that you are not using any medications that can affect its effect or whose effect can be influenced by this diuretic.
When combined with cardiac glycosides, it increases their effect on the myocardium, and also increases the potency of the therapeutic effect of curare-like muscle relaxants and theophylline.
Corticosteroid and laxative drugs when combined with Torsemide increase the risk of hypokalemia.
The drug potentiates the therapeutic effect of antihypertensive drugs, especially angiotensin-converting enzyme inhibitors. If these medications are prescribed to be used together, it is recommended to monitor blood pressure and adjust the dose of Torsemide and antihypertensive drugs to avoid hypotension (the arterial pressure lowering below the norm).
Torsemide reduces vasoconstrictor activity of epinephrine and norepinephrine, as well as the effectiveness of hypoglycemic agents.
The high doses of the medication, when combined with platinum drugs, enhance the negative effect of the later, as well as increase the nephrotoxic effect of cephalosporins and aminoglycosides. In addition, Torsemide increases the risk of development of ototoxic action of aminoglycosides and the negative effect of high doses of salicylates on the central nervous system.
Non-narcotic analgesics and probenecid, when combined with the diuretic, reduce the effectiveness of Demadex.
The drug when combined with lithium preparations increases their plasma concentration.
Colestyramine use with the simultaneous administration with Torsemide can reduce its absorption.
Adverse effects that can be caused by Generic Demadex use
In some patients, the use of the medication can cause the development of certain negative effects such as cerebral and cardiac ischemia, including accompanied by arrhythmia, angina, syncope and acute myocardial infarction, thrombosis, anemia, thrombocytopenia and leukopenia, anorexia, nausea, vomiting, stool disorders, pancreatitis, dry mouth, increased activity of hepatic transaminases, hypercritininemia, increased urea levels in blood plasma, urinary retention (predominantly in patients with urinary dysfunction), water-electrolyte imbalance, metabolic alkalosis, hyperglycemia, hyperlipidemia, itching, rash, urticaria, photosensitivity, angioedema, decreased visual acuity, noise in the ears, hearing impairment, and limb tremor.
If you experience any negative effects after you order Torsemide tablets and start the therapy, inform your physician about them.
Overdose signs and treatment
When taking Torsemide in doses that significantly exceed recommended ones, patients can develop forced diuresis, drowsiness, lower blood pressure (up to collapse), electrolyte balance disorders, confusion and increased side effects on the part of the digestive system.
There is no specific antidote. In case of overdose, gastric lavage and enterosorbents intake are indicated (if no more than 2 hours have passed after oral administration of the drug), as well as symptomatic therapy and measures aimed at restoring the electrolyte balance.
In case of an overdose of the preparation, it is advised to discontinue the therapy or the correct the daily dosage
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