Depakote (Divalproex 300 mg)
€39.95 – €92.90
The medication known as Depakote, Divalproex and many other trade names is valproic acid. It is a substance that suppresses and prevents seizures of different severity and migraines. The medication can be used in young children and adults but is preferably not used during the first three months of pregnancy. The formulation sold on this webpage is oral pills of different dosages – 300 mg and 600 mg. It can be also available in a form of oral syrup. The treatment must be started with the lowest possible dose and then the doses can be increased till the desired effect is achieved. Read the full guide to know more about the medication use.
What medication do you buy under the trade name Depakote?
The medication sold under the trade name Depakote was first used in medicine in 1962. It is a medication internationally known as valproic acid or Divalproex. Obviously, as in the case with other medications developed so many years ago, the right to make it and sell is not reserved to a single pharmaceutical company. It means that you can buy Depakote made by another company that cannot use this trademark but get the same effect at a lower price by the way.
This medication is a fatty acid derivative mainly used as an antiepileptic drug, as well as for the treatment of bipolar disorder and prevention of migraines.
How is the effect of the medication achieved?
The medication inhibits the gamma-aminobutyric acid-transferase, increases the content of gamma-aminobutyric acid in the central nervous system, which causes a decrease in the threshold of excitability and the level of convulsive readiness of the motor zones of the brain.
When ingested, it dissociates to valproate ion, which is absorbed into the blood plasma. Food decreases the absorption rate.
The max concentration in plasma is observed 1-4 hours after the dosage intake. The therapeutic concentration in the blood is 50-100 mcg/ml (may be significantly higher or lower, depending on the permeability of the blood-brain barrier in this patient).
Binding to plasma proteins of the medication is about 90%. It is metabolized in the liver: most of the glucuronidates, the smaller – oxidizes with the participation of either microsomal enzymes or in the mitochondria of hepatocytes (beta-oxidation). Metabolites and conjugates are excreted by the kidneys. A small amount of valproic acid is excreted in milk.
Can you buy Generic Depakote instead of the branded drug?
There is not a single reason against the purchase of the cheaper generic version of the mediation instead of the overpriced branded medicine that is more expensive only because of the known name.
The formula of the medication is known since the nineteenth century and obviously is no longer protected by the copyright. It allows numerous pharmaceutical companies to use it without infringing any laws. The generics use is even promoted as it allows people from different income groups to get equally effective treatment. But to be sure that you get the right medication especially if you purchase the pills online, make sure to check the name of the active substance which should be valproic acid and its amount per pill to get the right treatment.
When is Depakote or its generic used?
Depakote and all drugs with the same composition are appointed for the treatment of various forms of generalized seizures: small (absences), large (convulsive) and polymorphic, focal seizures, children’s tics, bipolar disorder, and migraines.
Although you can buy Generic Depakote from this webpage without a valid prescription, we still encourage you if you have any seizures or suffer from migraines to go to a doctor first to get properly tested before you start taking any pills as these symptoms can signalize that you need more complex and thought-through therapy.
When shouldn’t you buy Depakote?
The drug must not be used by people, who are hypersensitive to it, i.e. have severe allergic reactions to the pills including people who have history of family members’ deaths while using this drug. The medication must not be also used by people with pancreas or liver dysfunction and in the presence of hemorrhagic diathesis.
If you buy Divalproex while you have aplasia of the bone marrow, already use other anti-seizure medicines or plan to use this drug for therapy of children, make sure to consult a doctor as these factors are considered of high risk.
What adverse effects can Divalproex use cause?
When you get the medication, before you start taking it, you should be prepared that you may start suffering from certain side effects such as nausea, vomiting, diarrhea, pain in the abdomen, loss of appetite or increase of appetite, liver dysfunction, tremor, sleepiness, confusion, swelling, bleeding, and others.
If you have any allergic reactions or other reactions are severe – stop using Divalproex and talk to your healthcare provider.
Interaction of Divalproex with other medicines
When you buy Generic Divalproex, make sure to talk to your doctor about the possibility of using this medication with other ones that you use.
The effect of the drug is enhanced in the use of other anti-seizure meds, sedatives, antidepressants, antipsychotics, and sleeping pills.
Therefore, sometimes it is necessary to reduce the doses of these drugs. The use of medicines that negatively influence the liver function or alcohol along with Divalproex can cause more severe liver adverse reactions.
Anticoagulants, aspirin, and Divalproex mutually enhance the inhibitory effect on platelet aggregation, which requires strict control over the coagulating system of blood with the simultaneous use of these drugs. Besides, aspirin raises the concentration of Divalproex in the blood plasma what can lead to the enhancement of adverse effects of the latter.
To lower the digestive tract side effects, you can take antispasmodics and enveloping agents that protect the gastric mucosa.
How to use Divalproex?
Here we provide the information taken from the official instruction but you need to consult your healthcare provider for more precise advises suitable for your case when you order Depakote.
The medication can be taken either as a single drug or in combination with other anti-epileptic drugs.
In small forms of epilepsy, valproic acid is usually administered alone.
The medication is taken orally after a meal or during a meal. The treatment is started with small doses with a gradual increase within one to two weeks until the desired therapeutic effect is achieved. Then, the optimal maintenance dose is selected.
The daily dosage for adults at the beginning of the treatment is one or two pills 300 mg pills. Then it is gradually increased to 900 mg-1500 mg. The single intake dose is 300-450 mg. The maximum daily dose is 2400 mg.
For the therapy of migraines, it is desirable to stick to the low doses.
For the treatment of children, the dosages are selected individually based on the age, the severity of the condition, and therapeutic effect. Usually, the daily dose for children is from 20 to 50 mg per kilogram of the body weight. The maximum is 60 mg per kilogram. The treatment is started with 15 mg per kilogram then the dose is raised by 5-10 mg till the desired effect is achieved. The daily dose should be split into two-three intakes. It is convenient to administer the drug to children in a form of 5% syrup that contains 50 mg of the active substance per one milliliter.
300 mg, 500mg
40 pills, 60 Pills, 80 pills, 100 Pills