Flagyl (Metronidazol 200 mg)
€39.80 – €59.43
Flagyl is a brand name registered for the drug called internationally Metronidazole. It is used for the therapy of various bacterial infections, amebiasis, trichomoniasis, nonspecific vaginitis, surgical infections caused by anaerobic microorganisms, and so on. The medication can be used in children older than 6 years and in pregnant women during the second and third trimesters if the anticipated benefit is greater than the risks. Find out about the use of the medication, precautions, and side effects from the complete article below.
What is the product sold as Flagyl?
The brand name Flagyl is owned by a pharmaceutical company Sanofi Avensis. The same medication is also made and marketed by other pharmaceutical companies under the brand and generic names. For instance, in the U.S. it is sold under the same name Flagyl but it is made by Pfizer. Besides, the medication is made by numerous manufacturers such as Cipla, Abbott, and others and can be called differently. Some of the names under which you can find the same medication are Metrogyl, Metronidazole, Acromona, Clont, Cont, Monasin, Nalox, Neo-Tric, Nidagel, Noritate, Novonidazol, Orvagil, Protostat, Rathimed, Trichazol, Trichex, Tricho Cordes, Trichopol, and others. It is possible because the original substance was synthesized first in the 1960s and since then, the developer of the medication, a French pharmaceutical company Rhone-Poulenc had lost their exclusive rights to make the medication without sharing the formula with other drug makers. It is a common practice all around the world that after a certain period of time, the formula developer is obliged to give out the formula and other drug makers can make and sell their medicines with the same composition and effect without infringing the copyrights. It is made so to satisfy the world’s demand for the medications and make the drugs cheaper for the countries with lower average incomes.
Nowadays the medication is prescribed for the treatment of protozoal infections, infections of bones and joints, nervous system infections, sexually transmitted infections, vaginal infections due to a surgery, and so on. To treat these conditions you can buy Flagyl or opt for a generic with the active ingredient being Metronidazole.
Metronidazole, the active agent of Flagyl, is a synthetic derivative of the natural substance of azomycin, produced by Streptomyces spp. When first utilized in healthcare, the substance was considered exclusively an antiprotozoal agent for the treatment of trichomoniasis. The antibacterial effect of the medication was discovered by chance: when in 1962 a patient with trichomoniasis colpitis using Metronidazole had been cured of bacterial gingivitis.
How Flagyl acts?
The medication renders antibacterial, antiulcer, antialcoholic, antiprotozoal, anti-trichomoniasis, and antimicrobial effects.
The nitro group of the molecule, which is an electron acceptor, is built into the respiratory chain of protozoa and anaerobes (competing with electron transport proteins – flavoproteins, etc.), which disrupts respiratory processes and causes cell death. In addition, some species of anaerobes have the ability to suppress DNA synthesis and cause its degradation.
After the pill is taken orally, the active agent is quickly and fully absorbed from the digestive tract. The maximum level of the medication in the tissues is observed within one to three hours. It penetrates the tissues and fluids of the body well creating bactericidal concentrations in saliva, semen, vaginal secretions; penetrates the GEB and placental barriers, is secreted into breast milk.
People with impaired kidney function can accumulate the medication in the blood plasma. Therefore, it is advised to use lower doses or take the medication less frequently if creatinine clearance is lowered.
Can you replace the brand-name drug with Generic Flagyl?
Yes, without any doubts you can buy Generic Flagyl when your doctor prescribes you the brand-name medication because exactly the same medication is manufactured by numerous different companies who set the lower prices per pill.
You can use the medication as you would use the branded one but to be sure that you follow the right dosage regimen, make sure to check the dose of Metronidazole per pill.
When can you purchase Metronidazole?
You can buy Metronidazole only if an infection that caused your malaise is confirmed to be caused by a pathogen that is sensitive to the active agent of the drug. The medication is appointed to be used in infections caused by microorganisms that are sensitive to it such as amebiasis; genitourinary trichomoniasis; nonspecific vaginitis; giardiasis; infections caused by anaerobic microorganisms sensitive to Metronidazole that develop after surgery. Besides, the drug can be utilized as a substitute for intravenous treatment of infections caused by anaerobic microorganisms that are sensitive to it.
In some cases, when a doctor analyzes the results of your tests, he or she can prescribe you to use the medication without doing a susceptibility test as the full blood test will show the names of pathogens and an experienced doctor knows if they are or not sensitive to Metronidazole. In any case, before you purchase the pills to start the treatment, make sure to do all necessary tests.
When shouldn’t you buy Metronidazole?
Even if the tests show that you need the treatment with this medication, you should not use it if you are hypersensitive to the drug’s components or other derivatives of nitroimidazole, suffer or ever suffered from leukopenia, have organic diseases of the central nervous system (epilepsy), have hepatic insufficiency (the high doses are contraindicated).
You must not buy Generic Metronidazole and use it during the first three months of pregnancy, while you breastfeed, or give it to children without consulting a pediatrician first.
The drug is not advised to be used in any liver dysfunctions including the mild ones, in severe kidney dysfunction, central nervous system disorder, and during the second and third trimesters of pregnancy.
What negative effects can you expect from Generic Flagyl use?
The use of both brand-name Flagyl and its generic can cause minor gastrointestinal disorders such as epigastric pain, nausea, vomiting, diarrhea, glossitis with dry mouth, stomatitis, taste disorders, anorexia; pancreatitis; flushes, itching of the skin, rash, in some cases accompanied by an increase in body temperature, urticaria, angioedema, anaphylactic shock, and others.
In case the adverse effects are severe, especially if you have an allergy, you need to stop using the pills and inform your doctor promptly so that she or he will quickly advise you a drug replacement and you would be able to continue the therapy without the negative symptoms.
How to use Generic Flagyl?
If you have direct recommendations from a specialist who treats you how to use the pills, you should follow their advice without regard to the instruction. Here we share the information available in the official instruction.
The treatment of amoebic dysentery is treated in adults with 1.5 grams a day or two 500 mg pills taken three times per day. For kids older than six years, the dosage is 30-40 mg per kilogram of the weight.
Lambliasis is treated for five days. The dosage for adults is 750 mg or 1000 mg taken once a day. Kids aged from six to ten years are treated with 375 mg per day. Kids aged from ten to fifteen years are given 500 mg once a day.
Trichomoniasis in women, is treated for ten days, combining 250 mg (one tablet) two times a day and one vaginal suppository (500 mg) per day. The sex partner must be treated at the same time regardless of the presence or absence of signs of trichomoniasis and even if the laboratory tests are negative. The therapy of the infection in men is made for ten days with 250 mg (one tablet) taken twice per day.
In the most severe cases, the daily dosage can be raised to 750 or even 1000 mg.
If you order Flagyl for the treatment of nonspecific vaginitis, the recommended dosage is 500 mg taken twice a day for seven days. The sex partner must also undergo the therapy at the same time.
To treat anaerobic infections, adults are usually advised to take 1000-1500 mg (4-6 250 mg pills) a day. For children older than six years, the dosage is 20-30 mg per kilogram of the body weight. The dosages are split into two intakes.
During the therapy with the medication, you must avoid using alcohol as it can lead to the occurrence of such negative symptoms as spasms in the abdomen, nausea, vomiting, headache, flushes, and others.
During the treatment of trichomonas vaginitis in women and trichomonas urethritis in men, it is necessary to abstain from sexual activity. It is necessary to simultaneously treat sexual partners. After therapy of trichomoniasis, control tests should be performed for three consecutive cycles before and after menstruation.
Here you can find the most negative and dangerous combinations of drugs with Metronidazole. Check the list and consult your doctor if you use any medicines before you order Generic Flagyl.
It is contraindicated to combine the medication with alcohol due to the high risk of severe adverse reactions.
The drug should not be taken along with Disulfiram as this combination raises the risk of acute psychotic episodes or confusion.
Busulfan used in high doses along with Metronidazole is found in significantly higher amounts than it should in the blood plasma which is fraught with negative reactions.
The medication should be carefully combined with anticonvulsants that induce enzymes, Rifampicin, Lithium, Fluorouracil, and anticoagulants. If the therapy with these medications is inevitable when you use Metronidazole, make sure to discuss these drugs’ use with your doctor and follow his or her recommendations strictly.
Overdose of Flagyl
In the intake of high doses (more than 12000 mg), such symptoms can develop as nausea, vomiting, ataxia, in severe cases – peripheral neuropathy and epileptic seizures.
Treatment advised is symptomatic; there is no specific antidote.
200mg, 400 mg
100 Pills, 150 Pills