Generic Hepcinat (Sovaldi 400 mg) guide:
What is the medication you are offered to buy as Generic Hepcinat?
The medication known in several countries as Hepcinat is known internationally as Sovaldi or Sofosbuvir. Hepcinat is nothing more than trade name advertised and promoted intensely in the U.S. and some other countries so it became a recognized brand. People whom the medication is prescribed are convinced that it is the best medication to treat hepatitis C, and those other medicines are either fake or ineffective. In fact, it is not so.
Generic medications are made and approved as generics of certain brand medications only after they are thoroughly and rigorously tested. When you buy Generic Hepcinat you basically purchase Hepcinat in terms of the formula, effect, safety, and so on but under a different trade name. These different names are due to the fact that different drug manufacturers can make the same medicine but are unable to use the same name as it would infringe the copyright of the brand owner.
You should never doubt that the generic has the same effect as the branded medicine. They were meant to be exact replicas of the original medication and it’s not like with fashion clothing replicas made of inferior materials – generic medications are made using exactly the same ingredients and methods of production. These medications are created with the help of the World Health Organization as the part of the program aimed to make all the newest and most effective preparations affordable for everyone and available everywhere in the world. Generics help to satisfy the demand for the medications a single pharmaceutical company wouldn’t be able to satisfy.
Why is the generic cheaper? Is it inferior?
You may prick up by the low price of the generic especially if your doctor tells you that only Hepcinat is what you need. But you shouldn’t believe your doctor as there is a high chance that he is paid to prescribe namely this brand of the medication. Yes, pharmaceutical companies who own the brands pay doctors when they prescribe their medications. They are trying to promote the idea that generics are inferior so that people from the developed countries bought their medications instead of the cheaper analogs.
The cheap price of generic medication is not because of its inferior quality but because of several factors: no research and development costs as the formula is already discovered, lower production and advertising costs, and lower margins. In fact, even the branded medicines’ production doesn’t cost that much but the companies set high margins in pursuit of a big profit. Therefore, if you need the therapy of hepatitis C, you can order Generic Hepcinat from our online pharmacy without any worries that the medicine can be ineffective or unsafe for you and save 20, 000 dollars on the treatment.
When the medication is used?
Sofosbuvir, the active substance of both the branded drug and generic is an antiviral agent effective against the viral hepatitis C. The medication is widely used from the 2013 and is believed to be the most effective and safe treatment for the disease. Moreover, the therapy with the medication takes much less time than with the previously used preparations.
If you are diagnosed with hepatitis C, you can start using the medication but before that, you need to consult your doctor on the combination with other medicines and dosage regimens.
Who must not use the medication?
Although the medication is of the new generation and the condition it treats is life-threatening, there are some cases in which it cannot be used.
The main contraindication for the preparation use is increased sensitivity to the medication manifested in severe side effects, age below 18 years, and kidney insufficiency of the severe stage with less than 30 ml per minute creatinine clearance or in patients on hemodialysis. The safety of the medication is also unknown in patients with combined hepatitis C and B and decompensated liver cirrhosis.
The medication is not advised to be used in patients with hepatitis C of the genotypes 1,4,5, and 6 who previously received antiviral therapy especially if one or several factors related to the low response to the treatment with interferon are present such as, for example, widespread fibrosis/cirrhosis of the liver, initially high virus concentration, and others. You also should not buy Sovaldi and start using it if you already receive antiviral therapy such as telaprevir or boceprevir as their combination is considered unsafe.
How to use the drug for the therapy of hepatitis C?
Here you can find the general instructions for the drug. However, your health care provider can decide that you need another treatment regimen. To be sure that you treat the condition properly, please consult your doctor first before you buy Generic Sovaldi and start using it.
The recommended daily dosage is 400 mg or a single tablet taken orally without chewing with and washed down with a glass of water. The tablets are advised to be taken during meals and at the same time every day.
The dosage regimens and recommended combinations depend on the genotype of hepatitis C:
– Genotypes 1a and 1b are treated with a combination of Sofosbuvir plus Ledipasvir for from 8 to 12 weeks or in combination with Daclatasvir for 12 weeks.
– Genotype 2 is treated with a combination of Sofosbuvir plus Ribavirin or Daclatasvir for 12 weeks.
– Genotype 3 is treated with a combination of Sofosbuvir plus Ribavirin for 24 weeks or with Daclatasvir for 12 weeks.
– Genotype 4 is treated with a combination of Sofosbuvir plus Ledipasvir or Daclatasvir for 12 weeks.
The instruction also includes the recommendations for the therapy of hepatitis C and combination of hepatitis C with HIV in compensated liver cirrhosis including patients who hadn’t receive any therapy or received the therapy with interferon and Ribavirin but the virus didn’t respond:
– Genotypes 1a and 1b are treated with a combination of Sofosbuvir/Ledipasvir for 24 weeks or these two drugs plus Ribavirin for 12 weeks. Alternatively, it is treated with combination of Sofosbuvir with Daclatasvir for 24 weeks or these two drugs plus Ribavirin for 12 weeks.
– Genotype 2 is treated with Sofosbuvir/ Ribavirin for 16-20 weeks or with Sofosbuvir /Daclatasvir for 12 weeks.
– Genotype 3 is treated with Sofosbuvir /Daclatasvir plus Ribavirin for 24 weeks.
– Genotype 4 is treated with Sofosbuvir / Ledipasvir for 24 weeks or with Ribavirin for 24 weeks. Alternatively, Sofosbuvir /Daclatasvir are used for 12 weeks or these two medicines plus Ribavirin for 12 weeks.
What adverse reactions can you anticipate from the medication use?
When you buy Hepcinat and start using it, even if you follow your doctor recommendations, you can still suffer from certain side effects such as headache, loss of appetite, general weakness, fatigue, insomnia, depression, anxiety, inability to focus, and others. Some of the adverse effects are more likely in combination use of Sofosbuvir with Ribavirin, others are more typical for the combination Sofosbuvir plus Ledipasvir or Daclatasvir. Either way, if you start experiencing any malaise while you are undergoing the therapy with the medication, you should inform your health care provider and never postpone a visit to your doctor in case the side effects are intense.
Combination with other medications
Although the medication is commonly combined with other preparations to treat hepatitis C, its use with other preparations is not fully studied and thus isn’t considered safe. It is proven that some medications can lower the effect of the preparation. For instance, Rifampicin, St John’s-wort, Carbamazepine, and Phenytoin can lower the concentration of the medication in the blood plasma and therefore lower the drug’s effect. Thus, you should inform your doctor if you use or plan to use during the antiviral therapy any medication or supplement before you order Hepcinat and start using it.