Hyzaar (Losartan + Hydrochlorothiazide 12.5 mg)
€34.90 – €60.90
Hyzaar and its generic versions are combination drugs based on angiotensin II receptor antagonist Losartan and diuretic Hydrochlorothiazide. The drug is mainly used for the treatment hypertension but is also sometimes prescribed for edema, diabetes insipidus, and heart failure. The standard starting dosage for all conditions is 50 mg Losartan and 12.5 mg Hydrochlorothiazide or a single pill. The drug is allowed to be used in people with moderate liver or kidney failure but only under a doctor’s supervision. Hyzaar and its generics are contraindicated for pregnant and lactating women and children. More detailed information on the treatment course, adverse effects, contraindications, dosage adjustments, and measures in overdose can be found in the medication guide below.
Brand name: Hyzaar
Generic name: Losartan + Hydrochlorothiazide
Indications: Arterial hypertension (High blood pressure), Prevention of stroke, Prevention of myocardial infarction
Analogs: Acuretic, Aldactazide, Aldoril, Apresazide, Aquarills, Aquarius, Bremil, Caplaril, Capozide, Chlorosulthiadil, Chlorothiazide, Chlorzide, Cidrex, Dichlorosal, Dichlorotride, Dichlotiazid, Dichlotride, Diclotride, Dicyclotride, Dihydrochlorothiazid, Dihydrochlorurit, Direma, Disalunil, Diu-Melusin, Diuril, Drenol, Dyazide, Esidrex, Esidrix, Esimil, Fluvin, Hidril, Hidrochlortiazid, Hidroronol, Hidrotiazida, Hydril, Hydro-Aquil, Hydro-D, Hydro-Diuril, Hydrochlorothiazid, Hydrochlorthiazide, Hydrodiuretic, Hydrodiuril, Hydropres, Hydrosaluric, Hydrothide, Hydrozide, Hypothiazid, Idrotiazide, Inderide, Ivaugan, Jen-Diril, Lopressor Hct, Lotensin Hct, Maschitt, Maxzide, Megadiuril, Microzide, Moduretic, Nefrix, Neo-Codema, Neoflumen, Newtolide, Oretic, Palonyl, Panurin, Perovex, Primogyn, Prinzide, Ro-Hydrazide, Servithiazid, Thiaretic, Thiuretic, Thlaretic, Timolide, Unipres, Urodiazin, Vaseretic, Vetidrex, Ziac, Zide
Generic Hyzaar (Losartan + Hydrochlorothiazide 12.5 mg) guide:
What is Generic Hyzaar (Losartan with Hydrochlorothiazide)?
Generic Hyzaar is a medication based on two active substances Losartan and Hydrochlorothiazide. It is identical to the brand-name drug Hyzaar. Losartan is an angiotensin II receptor antagonist and hydrochlorothiazide is a diuretic.
What is the mechanism of action of Hyzaar (Losartan and Hydrochlorothiazide)? How does the drug act?
The effect of the drug is achieved through the synergic effect of its components. Angiotensin II receptor antagonist (Losartan) lowers the body organ’s responses to angiotensin II effect including the antagonizing of the release of aldosterone. It lowers the afterload of the heart and preload. The medication doesn’t affect renin-angiotensin system directly yet its activity is amplified because of the eliminated responses of the organs to angiotensin II action.
The diuretic (Hydrochlorothiazide) lowers the absorption of sodium on the level of cortical segment of the Henle loop, without affecting its area passing through the medulla of the kidney, which determines a weaker diuretic effect compared to other diuretics. It blocks carbonic anhydrase in the proximal part of convoluted tubules, strengthens potassium, bicarbonates and phosphates excretion in the urine. The drug practically doesn’t affect acid-base state, increases the excretion of magnesium and contributes to the retention of calcium ions, sodium and potassium salts of uric acid.
The diuretic effect occurs within 1-2 hours after the pill intake and lasts for 10-12 hours. The drug lowers the blood pressure through the reduction of the volume of the circulating blood, changes in the reactivity of the vascular wall, decrease in the pressor effect of vasoconstrictive drugs and depressor effect on the ganglion.
Considering that Losartan used as a single medication can cause hyperkalemia, Hydrochlorothiazide is a perfect companion for the drug as it promotes potassium excretion thus minimizing the risk of the life-threatening condition occurrence.
Warning: In people with diabetes insipidus, the medication renders antidiuretic effect (reduces the volume of urine and increases its concentration).
When should the drug be used?
You can buy Generic Hyzaar and use it for high blood pressure, heart failure, edema, diabetes insipidus, and renal tubular acidosis. Sometimes doctors find the drug to be suitable for the prophylaxis of kidney stones formation in people who have high levels of calcium in their urine.
If you have any of the listed conditions, it is still highly advised to consult your doctor first before you start using the drug as this particular medication may be not suitable for you or you may need a dosage adjustment selected by your doctor.
How to use Generic Hyzaar?
The general dosages are the following:
For the treatment of hypertension the initial therapeutic dosage is 50/12.5 mg a day. The dosage can be raised to 100/25 mg a day after 3 complete weeks of the treatment if no side effects develop.
For other conditions the starting dosage is the same though adjustments to lower the dosage or increase it can be needed.
What are contraindications for the medication use?
You should not buy Generic Hyzaar (Losartan + Hydrochlorothiazide) if you are allergic to one or several components of the drug or any sulfanylamide derivatives, suffer from anuria (the urine doesn’t enter the bladder).
The drug is also contraindicated for children, pregnant and breastfeeding women.
The drug is contraindicated during pregnancy, especially during 2 and 3 trimesters because of the possible pathologies in the fetus development or even death of the fetus. As for the use in breastfeeding, the drug can penetrate the milk, so it is better either to stop breastfeeding for the therapy period or use another medication instead.
The drug should be cautiously used in liver and kidney insufficiency. It is not recommended for people with creatinine clearance lower than 30 ml per minute. During the treatment, it is recommended to monitor water-electrolyte balance, the content of glucose, cholesterol and triglycerides in blood plasma. Is a patient uses drugs for diabetes dosage adjustment of Hyzaar may be required.
What side effects can Hyzaar (Losartan and Hydrochlorothiazide) cause?
The most frequent adverse reaction of the medication is dizziness. However, when you prepare to buy Generic Hyzaar (Losartan + Hydrochlorothiazide) and use it, you should be ready to experience other side effects such as headache, edema, fast or irregular heartbeat, muscle stiffness, abdominal pain, nausea, vomiting, flu-like symptoms, and others.
If you have any of these or other symptoms, make sure to inform your doctor. If the symptoms such as rapid heart rate, dizziness, fainting, and troubled breathing are severe, seek urgent medical assistance.
What combination of Hyzaar (Losartan plus Hydrochlorothiazide) with other drugs can result in?
The drug can be used along with other antihypertensive drugs which your doctor chooses for you.
The incidence of hypotension is increased in the combined use of the medication with alcohol, barbiturates, and narcotic analgesics.
Corticosteroids and adrenocorticotropic hormone combined with Hyzaar can cause loss of electrolytes and hypokalemia (low potassium level).
The medication enhances the effect of antidepolarizing muscle relaxants and the toxicity of Lithium-based drugs.
Generic Hyzaar (Losartan plus Hydrochlorothiazide) lowers the effect of adrenomimetics.
Cholestyramine and cholestipol reduce the drug absorption in the digestive tract and its effectiveness.
Nonsteroidal anti-inflammatory drugs lower the diuretic, natriuretic and hypotensive effects.
What should you do in the overdose with Hyzaar (Losartan/Hydrochlorothiazide)?
The most probable symptoms of the overdose include hypotension and rapid heart rate, hypokalemia, hypochloraemia, hyponatremia, and dehydration.
The elimination of the negative symptoms can require hospitalization. The measures to cope with the overdose symptoms include correction of dehydration, electrolyte disorders, hypotension and liver function, with the preliminary cancellation of the drug and gastric lavage (if the drug is taken recently).
Is there a difference between the brand-name drug and the generic’s effect and safety?
The drugs are identical. According to the rules established by the World Health Organization, generics are drugs that coincide in the effect, safety, indications for use, performance, dosage, and route of administration to the brand-name drug based on the same active substance. Therefore, if you plan to purchase a generic of the drug you need from a reliable seller like Rx shop, you can be a hundred percent sure that you will receive the same medication as your doctor prescribed.
If you are not sure what drug you need, you can always contact our pharmacists and get a free of charge consultation on the active substances of the drugs, their dosages, manufacturers and registered trade names.
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