Motilium (Domperidone 10 mg)
€39.80 – €94.60
Motilium or Domperidone are the same medicines only made by different companies. They are used for the digestive tract discomfort such as a feeling of heaviness after meals, nausea and vomiting, and others. The pills are recommended to be used only by adults and children older than sixteen years but if a pediatrician approves, younger children can be also given the pills. Please read our medication guide before ordering the pills to find out whether they are suitable for you or not.
What is the drug sold as Motilium?
The name of the medication Motilium is registered by a Belgium pharmaceutical company Janssen Pharmaceutica. The original formula of the active agent, Domperidone, was developed back in 1974. Currently, the exclusive patent had already terminated which means that the same formula can be used by other medication-making companies. Taking this into account, if your healthcare provider tells you to buy Motilium, you can get the generic version of the medication instead, i.e. the same medicine simply sold under another name. The most known alternative names for it are Dompy, Domstal, and Vomistop.
The medications based on Domperidone are antiemetics (anti-nausea meds) that normalize functions of the digestive system. They are also prokinetics, i.e. medicines that normalize the digestive motility by raising the frequency or potency of contractions in the small intestine.
How the medication’s effect is achieved?
The effect of the medication is due to the blocking of dopamine D2 receptors and inhibition of dopamine impact on the gastrointestinal tract functions. Domperidone raises the duration of peristaltic contractions of the antral part of the stomach and duodenum, improves the functioning of the stomach, accelerating its emptying in case of slowing down of this process, and increases the tone of the lower esophageal sphincter.
The anti-nausea effect is due to the combination of peripheral (gastrokinetic) action and blockade of chemoreceptors in the trigger zone of the vomiting center. Domperidone prevents the development or reduces the severity of nausea and vomiting. It also elevates serum prolactin levels. Domperidone does not affect gastric secretion.
When you buy Generic Motilium, you should know that it is quickly absorbed from the digestive tract but the food intake or the lowered gastric juice acidity lower the absorption and the effect is respectively less pronounced.
According to the tests of the medication in animals, as well as low concentrations in people, indicate a predominantly peripheral effect of Domperidone on dopamine receptors.
The maximum concentration of the active agent is achieved within a half of an hour or an hour after the pill intake. It is excreted mainly in feces and in smaller amounts in urine. In people with the impaired liver function, the medication can be accumulated in the body.
Can you purchase Generic Motilium in place of a branded medication?
There is no reason for you to avoid generic medication and pay more money for the branded drug as they are the same. When Domperidone was first introduced, it was made by a single pharmaceutical company who developed it but since the patent doesn’t protect the exclusive production of this formulation as all of them expire sooner or later, all other pharmaceutical companies can make the same medicines. And taking into account that they didn’t spend millions on research and promotion of their medications, they usually price their meds cheaper.
How can you know if you get the right medication when you order Generic Motilium online?
If you want to save even more on the treatment, the best option is to order Generic Motilium online from a pharmacy that is located in the country where all medications are overall cheaper than, for instance, in the U.S. To be sure that you are getting the right medication, make sure to verify that the active agent of the medication is Domperidone and the dosage of it per pill is the same as the dosage in Motilium. If you cannot find this info on the product page, do not hesitate to contact customer support of the pharmacy you chose to clarify these details.
When can you order Motilium?
Before you start using any medication, it is advised to consult a doctor. This medication can be used for nausea and vomiting due to of functional and organic diseases, infections, with toxemia, radiation therapy, diet disorders, drug origin, incl. when taking agonists dopamine-levodopa, bromocriptine, carrying out an endoscopic and radiopaque examination of the digestive tract. It is also appointed for the dyspeptic disorders on the background of delayed stomach emptying, gastroesophageal reflux disease: sensation of heaviness in the upper abdomen, a sensation of bloating, pain in the stomach, burping, bloating, heartburn with or without casting the gastric juice into the mouth; hiccough, atony of the digestive tract; the need to accelerate motor function of the stomach for certain medical examinations.
You can buy Domperidone from out online pharmacy without a prescription to cope with the symptoms described above but we still strongly advise you to consult a gastroenterologist and do all necessary tests to find out the reason behind these symptoms.
When is Motilium contraindicated to be used?
You shouldn’t use the medication if you have any previous negative experience with it, i.e. if you have ever used it and suffered from side effects, and especially if you suffered from allergic reactions. Besides, it is contraindicated to take the Motilium pills if you have gastrointestinal hemorrhage, mechanical intestinal obstruction, perforation of the stomach or intestine (stimulation of peristalsis can aggravate these conditions), hyperprolactinemia, and prolactinoma;
The formulation of Domperidone in pills is contraindicated to be used in children aged younger than five years and/or with the body mass less than twenty kilograms (44 lbs).
The medication can be but not advised to be used in liver or kidney dysfunction, during pregnancy and breastfeeding.
What are possible adverse effects of Motilium?
The use of the medication can be accompanied by the following negative reactions: spasm of the gastrointestinal tract muscles, dryness in the mouth, thirst, heartburn, stomatitis, loss of appetite, constipation or diarrhea, extrapyramidal disorders, headache, irritability, nervousness, sleepiness, seizures, lethargy, allergic conjunctivitis, skin rash, itching, urticaria, edema, menstrual irregularities, changes in frequency of urination, painful urination, irregular heartbeat, and others.
If when you buy Generic Domperidone and start using it you start suffering from any adverse effects, consult your doctor about how you should cope with them. If you have allergic reactions, stop using the medication immediately and ask your doctor about an alternative medication.
How the medication interacts with other medicines and substances?
Before you order Motilium, make sure to check that you are not using any medicines that can influence its effect or which effect can be influenced by Domperidone. Here you can find a shortened list of interactions but you need to consult a specialist if you are unsure whether the drugs you use fall into one of these categories or not.
The bioavailability (the amount of drug active in the body) of Domperidone is lowered in combined use with antacids and antisecretory drugs.
The effect of the preparation is diminished in combined use with anticholinergics.
Inhibitors of CYP3A4 isoenzyme cytochrome P450, for instance, certain antifungal medicines, macrolide antibiotics, and HIV medicines, slow down the metabolism of the medication and can contribute to its elevated levels in the blood plasma which is why it is advised to render caution when combining them.
Motilium should be cautiously used with MAO inhibitors.
Overdose of Generic Motilium
The signs of an overdose are sleepiness, irregular heartbeat, lowered arterial pressure, and extrapyramidal disorders.
The first measures are the intake of sorbents (for instance, activated charcoal), in the development of extrapyramidal disorders, anticholinergics or antihistamines with anticholinergic activity, and drugs used to treat Parkinsonism are used.
How to take Generic Motilium?
If when you order Domperidone you don’t have indications from your doctor on how to use the drug, you can follow the instruction but only under the condition that you have no contraindications for the medication use.
It is advised to take Motilium or Domperidone pills before meals as if taken with food the effect of the medication can be lowered. You need to keep the pill on the tongue before it’s partially dissolved and then swallow it.
To cope with the discomfort in the stomach after meals, adults and children older than sixteen years are advised to take up to 10 mg thrice a day. The maximum course duration is two weeks.
To get rid of nausea and vomiting, the medication should be taken by adults and children older than sixteen years by 10 mg thrice a day. The maximum treatment course length is 48 hours. If nausea and vomiting persist after 48 hours of pills intake, it is required to stop using the pills and visit a doctor. Besides, the medication is not advised to be used in the sea or air sickness.
The use in children younger than sixteen years is not recommended unless pediatrician prescribes special doses.
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