Description

Motrin is a trademark owned by Johnson & Johnson Consumer Inc. It is a commercial name for the internationally known medication Ibuprofen. It is basically a cheap medicine that is available under different names but when you buy Motrin, a promoted and advertised medication, you pay additional money for the brand.

The medications based on Ibuprofen are used for symptomatic therapy of a headache, toothache, dysmenorrhea, neuralgia, back pain, the ache in joints, muscles, in rheumatic pains, as well as signs of cold and flu. Since the medication is sold without a prescription in the majority of countries, it is usually used as an emergency aid before the diagnosis is made.

How does the medication act?

The effect of Motrin is due to the inhibition of cyclooxygenase type one and two and suppression of the production of prostaglandins. The effect of inflammation reduction is explained by the decreased vascular permeability, improved microcirculation, reduced release of inflammatory mediators from cells, and suppression of energy supply of the inflammatory process.

The painkiller effect is explained by the diminishing of the intensity of inflammation, a diminishing in the production of bradykinin and its effect. In rheumatoid arthritis, the medication affects mainly the exudative and partly the proliferative components of the inflammatory reaction. It has a quick and pronounced painkiller effect, diminishes puffiness, morning stiffness, and limited mobility in the joints.

Reducing the excitability of the heat-regulating centers of the intermediate brain is resultant in antipyretic action. The potency of the anti-fever effect is contingent on the initial body temperature and the dose taken. In the intake of a single dose, the effect lasts up to eight hours.

In dysmenorrhea, the medication contributes to the lowering of the intrauterine tension and the rate of uterine contractions. It also reversibly inhibits platelet aggregation.

How fast the medication starts acting and how soon it’s washed out of the body?

When you buy Generic Motrin you expect the medication to act fast as it’s an emergency medication. Indeed, the medication is well absorbed from the stomach into the blood and the maximum concentration of it is reached within just an hour.

It slowly penetrates into the joint cavity, but lingers in the synovial tissue, creating in it greater amount than in the plasma. After the absorption, around sixty percent of the inactive form is transfigured into an active one through a biotransformation. There are 3 main metabolites that are washed out by the kidneys. Around one percent is washed out in urine in an unaltered form. The regular pills are excreted from the body within two to three hours. The extended-release forms are washed out within twelve hours.

Does Generic Motrin render the same effect as the branded medicine?

The original medication on which Motrin is based, Ibuprofen, was first synthesized in 1962. Since then, the exclusive patent that allowed only the inventor to make and sell the medicine expired. It means that nowadays any drug-making company is able to use the formula and make their own medicines identical to the original Ibuprofen. Knowing that you can without any doubts buy Ibuprofen under any name and get the same treatment results as long as the active substance is correct and the dosage per pill corresponds to the one you need.

When can you use Ibuprofen?

You can use the medication as the first aid in a headache, period cramps, tooth ache and neurological pain in the back, for degenerative conditions of the muscle, joint and bone system such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, thoracic radicular syndrome, neuralgia, arthralgia, bursitis, tendonitis, hematomas, traumatic inflammation of soft tissues, postoperative pain syndrome with inflammation, and others.
Besides, you can buy Generic Ibuprofen for feverish conditions of various genesis, flu and upper respiratory tract infections. It can be used as an auxiliary treatment in tonsillitis, sinusitis, rhinitis, bronchitis, pneumonia, pelvic inflammatory processes, nephrotic syndrome (to reduce the expression of proteinuria), and others.

When is Motrin contraindicated to be used?

Although the medication is frequently sold over-the-counter, it has quite a number of prohibitions for use: intolerance of the ingredients of the pills, erosive and ulcerative illnesses of the digestive tract, bronchial asthma, NSAIDs intolerance,  blood clotting violation,  stomach bleeding; severe renal failure, brain injury, elevated intracranial pressure, hemorrhage,  impaired color vision, optic nerve disease, severe liver dysfunction, after coronary artery bypass surgery, hyperkalemia, last three months of pregnancy, age under six years (for regular pills), and age under twelve for extended release pills.

If you have one of the below-listed conditions, make sure to use the medication cautiously (preferably, consult a healthcare provider) if you order Motrin: liver cirrhosis, peptic and/or duodenal ulcer, liver and/or kidney failure, nephrotic syndrome; elevated arterial pressure; ischemic heart disease, cerebrovascular disease, arteries disease, diabetes, H. Pylori infection, prolonged use of NSAIDs, alcohol abuse, severe somatic diseases, use of certain medications, and any blood disease.

For a complete list of conditions and drug combinations that require caution please read the full instruction that accompanies the pills.

Do not combine Motrin with

The medication is highly not advised to be used along with cardiac glycosides, anticoagulants, antiplatelet agents, selective serotonin reuptake inhibitors.
It is advisable to avoid the simultaneous use of two or more NSAIDs as the risk of their adverse reactions increases several times.
The concurrent use of this medication diminishes the anti-inflammatory and antiaggregatory action of aspirin.
When used with thrombolytic and anticoagulant medicines, the risk of bleeding is elevated.
Cefamandole, cefoperazone, cefotetan, and valproic acid use raise the likelihood of hypoprothrombinemia development.
This is a short list of Motrin interactions with other medicines, for more detailed information please read the label, or consults your healthcare provider before you order Generic Motrin.

Adverse effects that can be caused by the use of Motrin

Before you order Ibuprofen, you should know that the use of the pills can provoke the occurrence of certain negative effects such as nausea, vomiting, loss of appetite, pain and discomfort in the abdomen, irritability, dryness in the mouth, ulceration of the mouth, stomatitis, pancreas dysfunction, constipation or diarrhea, bloating, digestive disorders, erosions and ulceration of the gastrointestinal tract, bleeding of the digestive tract, liver dysfunction, headache, anxiety, irritability, confusion, hallucinations, hearing impairment, noise in the ears, violated vision, swelling and irritation of the eyes, heart failure, tachycardia, elevated blood pressure, eosinophilia, anemia, thrombocytopenic purpura, agranulocytosis, leukopenia, and others.

The risk of the adverse effects and their severity increases in the prolonged use of the medication. If you experience any of the negative symptoms, discontinue using the pills and consult a physician.

Dosage regimen and special precautions

When you order Generic Ibuprofen, you should know that this medication is used for a short-term elimination of symptoms only.
It is recommended to take the minimum effective dose for three to five days for the elimination of fever. If the symptoms do not go away, you need to go to a doctor.
Adults and children with the body mass more than thirty kilograms should take 200-400 mg every four to six hours if needed. The pills should be swallowed without chewing and washed out with sufficient amount of water.
The preparation is allowed to be used by adults and children with the body mass more than twenty kilograms and aged older than six years.
The pills are taken after a meal to diminish the possibility of digestive tract adverse effects.
For the therapy of osteoarthritis, psoriatic arthritis and ankylosing spondylitis the dosage for adults is 400-600 mg taken from three to four times a day. For rheumatoid arthritis therapy, the dose is 800 mg three times daily. For the therapy of soft tissues injuries, the daily dose is 1600-2400 mg in several intakes.
For children older than twelve years the daily dose is 450-900 mg split into three intakes. The maximum dose is 1000 mg. Then, the dose should be lowered to 300 mg split into three intakes. For the therapy of juvenile rheumatoid arthritis, the recommended dosage is 30-40 mg per kilogram of the body weight in several doses.
People with mild to a moderate liver or kidney dysfunction and people of old age do not require dosage reduction.

Overdose of Motrin

The typical manifestations of an overdose are the pain in the abdomen, nausea, vomiting, sleepiness, depression, headache, noise in the ears, and cardiac symptoms.
The treatment implies gastric lavage performed within an hour after the oral pills intake, intake of activated carbon or other sorbents, forced diuresis and symptomatic therapy.