Nexium (Esomeprazole 20 mg)
€43.60 – €94.20
Nexium is just one of the names under which the active substance Esomeprazole is sold. Esomeprazole is a proton pump inhibitor that is used in peptic ulcer of the stomach and duodenum, as a prophylaxis of ulcer in risk groups, i.e. people who take NSADs, for gastroesophageal reflux disease, and so on. Read our full guide to know how and for how long to use the capsules in your condition and what adverse effects can you expect to develop from the medicine use.
What are the pills called Nexium?
The medication sold as Nexium is based on the substance called Esomeprazole. The medication is sold not only under the brand name but also under the so-called generic names. It means that it is produced by various manufacturers who use the same formula and make the same drug but cannot use the name that is registered by a certain company. You can buy Generic Nexium from a reliable seller like our online pharmacy and enjoy the same effect as from the branded drug for less money.
The medication is a proton pump inhibitor that blocks the excessive secretion of gastric juice and is used in various gastrointestinal conditions including ulcers.
How do Esomeprazole pills act?
The activity of the medication is explained by the suppressed production of hydrochloric acid in the stomach through affecting certain target mechanisms. It is an inhibitor of proton pump in the certain cells of gastric mucosa.
The medication starts to act only in a strongly acid medium of the secretory tubules of parietal cells, where it suppresses the proton pump action, i.e. the certain enzyme. It suppresses the basal (on a hungry stomach) and provoked production of gastric juice.
After taking the prescribed dosage, the therapeutic effect is developed within an hour. In everyday intake in the dose twenty milligrams once a day, the average maximum production of gastric juice is lowered by 90% if measured six-seven hours after the pill intake on the fifth day of therapy.
Effectiveness of the drug
In the use of Nexium or a generic medication based on Esomeprazole for gastroesophageal reflux disease in the dose of forty milligrams a day, the complete cure of the condition is observed in around eighty percent of patients after a complete four-week treatment course. In eight weeks, the complete cure is observed in 93% of patients. Do not forget that if you need a longer treatment course, you can always buy Nexium in a generic form, i.e. the same drug with a less promoted name, to get the same results for less money.
When the medication is used along with prescribed antibiotics for the treatment of H. Pylori for one week, according to clinical trials, the success was achieved in 90% of patients.
People with uncomplicated ulcer of duodenum after a one-week course of the drug use do not require the following use of means to suppress the secretion of gastric juice for efficient treatment of ulcers and relieve of the symptoms.
The efficiency of the preparation in hemorrhage from a peptic ulcer had been observed in tests in patients with bleeding. The results are endoscopically confirmed and documented.
During the two comparative studies of Esomeprazole with ranitidine, Esomeprazole proved itself to be more successful in the therapy of peptic ulcers in patients who received nonsteroidal anti-inflammatory drugs.
Can you buy Generic Nexium instead of the branded medicine?
Considering that some of the conditions treated with the drug require long-term treatment, many people prefer to opt for generics instead of the branded medicines as they are cheaper. There is not a single problem with generics as long as you buy them at the reliable drugstores and verify the active substance name and dosage per pill before you make a purchase. However, when you buy Generic Esomeprazole, you need to be prepared that Generic Nexium is not a registered trademark but a collective term and that you will see a different name on the box of pills. It is a normal practice and the name doesn’t influence the quality of the medication. You need only to get a proof that the active agent’s name is Esomeprazole and the dose per pill corresponds to your doctor’s appointment.
When can you purchase Nexium or a generic drug with the same composition?
The medications with Esomeprazole in their composition are appointed for gastroesophageal reflux disease, erosion treatment and prophylaxis, ulcer of the stomach and duodenum (as part of a complex therapy in H. Pylori presence), acid-suppressing therapy in people who had bleeding from an ulcer, treatment and prophylaxis gastric ulcer caused by prolonged intake of NSAIDs Zollinger-Ellison syndrome or other diseases characterized by abnormal hypersecretion of the gastric acid, incl. idiopathic hypersecretion.
If you have the symptoms such as heartburn, overfilling of the stomach, reflux into the esophagus of gastric and/or duodenal contents, pain in the stomach, bloating, diarrhea, and so on for a week or more, visit a doctor to get a precise diagnosis. If you buy Esomeprazole without finding out the reasons for your symptoms, you can temporarily suppress the symptoms but overlook the main condition that will only get worse.
When shouldn’t you buy Esomeprazole?
It is contraindicated to use the medication in allergy to the active agent of the drug and substituted benzimidazoles. It is contraindicated to combine the drug with atazanavir and nelfinavir, use the pills during gestation and breastfeeding, and in age up to twelve years.
On top of that, it is not encouraged to take the pills in recent surgeries of the digestive, in jaundice, severe liver function impairment, and severe renal failure.
Precautions when using the medication
All medications that suppress the release of gastric acid and result in the reduced acidity of its content, including the proton pump inhibitors, can contribute to the rise of the number of bad bacteria in the stomach. The risk rises especially in the continuous use of the drug.
In the development of any of the unusual symptoms during the use of this medication such as, for example, significant spontaneous weight loss, frequent vomiting, dysphagia, vomiting with blood, and others, as well in the presence of stomach ulcer or a suspected ulcer it is crucial to get tested to exclude the development of malignant tumor as Esomeprazole can suppress the symptoms and delay the correct and timely diagnosis.
Besides, before you order Generic Esomeprazole or if you already take it without your doctor’s appointment, you obligatorily need to consult a specialist in case you have a history of a stomach ulcer or any surgeries on the digestive tract, if you have been undergoing uninterrupted symptomatic therapy of dyspepsia and heartburn for four weeks or more, if you develop jaundice or severe liver function disorder, if you are 55 or older if the common digestive tract symptoms are different then they were or new ones develop.
What are possible adverse effects of Esomeprazole?
The medication is generally well tolerated but yet, when if you order Nexium for the first time, be prepared that you may experience the following negative reactions: headache, pain in the abdomen, loose stool, bloating, nausea, vomiting, uncleared bowels, thrush, increased activity of liver enzymes, encephalopathy in patients with prolonged severe liver disease, hepatitis, liver failure, skin rash, itching, hives, dizziness, dry mouth, blurred vision, and others.
You don’t have to worry if the side effects are from mild to moderate unless you develop an allergic reaction. If you do see signs of an allergy even if they are mild, stop using the medication without any delay and seek a replacement.
How to use Nexium?
If you order Generic Nexium for gastroesophageal reflux disease accompanied by erosive reflux esophagitis, you should take 40 mg a day in one intake for four weeks if not appointed otherwise by your doctor. If the progress isn’t sufficient after four weeks, the use of the pills can be continued for four more weeks.
For prolonged prophylactic therapy in people with cured erosive esophagitis to avoid recurrence the medicine is prescribed to be taken by 20 mg once a day for as long as the doctor believes is needed.
For the therapy of gastroesophageal reflux disease, the daily dosage is 20 mg for four weeks. If after the full therapy the symptoms do not go away, it is needed to do additional tests. After the symptoms are eliminated, the medication can be taken as needed by 20 mg a day, for instance, if you are about to eat a meal you know is provocative for your stomach that is likely to provoke a reflux.
For the therapy of ulcerative stomach and duodenum disease, the medication is combined with antibiotics aimed to eliminate the pathogen that caused the disease, i.e. Helicobacter pylori, the medication is prescribed to be taken by 40 mg a day split into two intakes. The average duration of the treatment course is from 7 to 14 days.
People who have been using nonsteroidal anti-inflammatory drugs and developed peptic ulcers should take 20 mg once a day for four to eight weeks. For the prophylaxis of peptic ulcers caused by nonsteroidal anti-inflammatory drugs, the medication is taken by 20 mg once a day for as long as the doctor recommends.
The pills should be swallowed entirely and washed down with water. The pills must not be crushed or chewed as this will eliminate their effect. If a patient who is prescribed to take the pills has trouble swallowing them, they should dissolve the tablet in a glass of water and no other liquid and then drink all micro granules during the thirty minutes after the capsule shell dissolved. Do not chew or crash micro granules that are contained in the capsule.
People who are unable to swallow are administered the micro-granules without the capsule shell through the nasogastric tube.
Since the medication lowers the gastric acidity, it can lead to the lowering or increase of absorption of other medicines which behavior in the body depends on the pH of the stomach juice. As in the use of other agents that inhibit the secretion of hydrochloric acid, or antacids, the use of Esomeprazole may cause a diminishing of the absorption of certain drugs and enhance in the absorption of such drugs as digoxin.
The medication interacts with some of the antiretroviral (HIV and AIDS) medicines.
The simultaneous use of Nexium with Atazanavir substantially lowers the bioavailability of the later.
These are only some of the notable interactions. Please refer to the complete instruction or consult your doctor before you order Esomeprazole if you use any other medications.
Overdose of Esomeprazole
The overdoses of the drug are quite rare. The intake of doses higher than 280 mg can cause general weakness and digestive tract side effects.
The only needed treatment is symptomatic one, i.e. aimed to cope with the symptoms.
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