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O-Desmethyltramadol (O-DSMT, desmetramadol) is an opioid analgesic and an active metabolite which is produced in the liver after the consumption of tramadol. It has little to no history of human usage but is easily accessible through the use of certain online research chemical vendors.

In comparison to tramadol, O-DSMT is reported to be less stimulating and feels considerably closer to a traditional opiate. Being the metabolite that is mainly responsible for the analgesic effect of tramadol, O-DSMT is significantly more potent by weight than its parent compound.o-dsmt vendor

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