Ponstel (Mefenamic Acid 250 mg)
€39.80 – €57.48
Ponstel is nothing more than one of the commercial names for Mefenamic acid. It is a nonsteroidal anti-inflammatory medication used for a variety of conditions, for instance, painful menstruations, flu, joint diseases, traumas, toothache, and others. The pills can be administered to children older than five years. Read our full guide to know how and when to take the pills properly and for how long to avoid doing any harm to your body.
The medication known in some countries mostly as Ponstel is actually a medical compound called Mefenamic acid. It was developed in 1963 as a painkilling and anti-inflammatory substance that can be used in acute respiratory viral infections and influenza, pain of low and medium intensity caused by muscle injury, menstrual pain, dental ache, and headache of various etiologies, postoperative and postnatal pain, and so on.
You can buy Ponstel or the same drug under a different name and get absolutely the same effect as long as the active ingredient is Mefenamic acid. Under less known names, the medication is usually cheaper. It is viable since the patent for the formula use is expired and all pharmaceutical companies are able to utilize the formula and market their own medicines with the same compound.
How is the effect of Ponstel achieved?
The anti-inflammatory effect of the preparation is due to its ability to suppress the production of inflammation mediators such as prostaglandins, serotonin, kinin, and others. Besides, it is partially caused by the lowering of the level of lysosomal enzymes involved in the inflammatory response. Mefenamic acid stabilizes protein ultrastructure and cell membranes, reduces vascular permeability, disrupts oxidative phosphorylation, suppresses the synthesis of mucopolysaccharides, inhibits cell proliferation in the inflammatory focus, increases cell resistance, and stimulates wound healing. Antipyretic properties are associated with the ability to inhibit the synthesis of prostaglandins and influence the center of thermoregulation.
After the oral intake of Ponstel pills, the active agent is quickly and almost completely is absorbed from the digestive tract into the blood. The maximum level of it in the blood is achieved within two to four hours after the pill intake. It is metabolized in the liver and the half-life is from two to four hours. Ponstel is washed out from the body in an unchanged form and in form of metabolites with urine (the major part) and feces.
When can you use Generic Ponstel?
You can buy Generic Ponstel for the fast removal of inflammation and fever caused by acute respiratory infections and flu, in mild to moderate muscle, joint, traumatic, tooth, and headache, as well as for postoperative and postnatal pain.
You can be appointed to take the pills in primary dysmenorrhea (painful periods), dysfunctional menorrhagia, including those caused by the presence of intrauterine contraceptives in the absence of pathology of pelvic organs.
The medication is also used for a short-term therapy of inflammatory diseases of the musculoskeletal system such as rheumatoid arthritis, rheumatism, and others.
When must not you buy and use Ponstel?
The medication is contraindicated to be used if you are intolerant of the drug’s components, bronchial asthma, bronchospasm, rhinitis, hives (incl. history), which arose after the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.
Besides, the medication is prohibited to be used in the stomach and duodenal ulcer, including history, inflammatory bowel disease, hemopoiesis, severe heart failure, severe liver or kidney dysfunction, gastrointestinal bleeding or perforation caused by the use of non-steroidal anti-inflammatory drugs.
You should not buy Mefenamic acid and use it simultaneously with other, even selectively acting NSAIDs.
How does Mefenamic acid should be used?
The medication should be used under a doctor’s supervision. Only a doctor can choose the correct dose and treatment course length not to harm your overall health.
To avoid side effects from the gastrointestinal tract, it is advised to take the pills after a meal and wash down with milk.
Adults and kids older than twelve years are usually recommended to take 250-500 mg three to four times a day. If the medication is well tolerated but the effect is insufficient, the daily dose can be raised to 3000 mg. Then, when the therapeutic effect is achieved, the dose should be lowered to 1000 mg a day.
Children aged from five to twelve years are advised to be administered 250 mg three or four times daily.
The usual treatment course to relieve the pain syndrome is around seven days.
The therapy for the diseases of bones can last from twenty to sixty days or even more at doctor’s discretion.
Children under the age of five years are contraindicated to be administered the medicine.
What are possible adverse effects of Ponstel use?
The most common adverse effects are related to the gastrointestinal tract functioning and they include pain in the epigastric region, anorexia, heartburn, nausea, flatulence, vomiting, enterocolitis, colitis, aggravation of colitis and Crohn’s disease, gastritis, jaundice, hepatitis, pancreatitis, liver dysfunction, hemorrhagic gastritis, ulcer with or without bleeding, gastrointestinal bleeding, dyspepsia, constipation, diarrhea, and others. The likelihood of these symptoms occurrence is elevated if a patient who takes the medication already suffers from any gastrointestinal tract disorder or disease. If you do have any symptoms of the gastrointestinal disorder, make sure to consult a specialist before you buy Generic Mefenamic acid.
Other possible side effects include ringing in the ears, otalgia (earache), dyspnea, bronchospasm, dysuria, cystitis, impaired renal function, albuminuria, hematuria, oliguria, or polyuria, insomnia, weakness, irritability, agitation, headache, blurred vision, convulsions, optic neuritis, paresthesia, dizziness, stiff neck, fever, loss of orientation; hypersensitivity reactions, including rash, skin itch, face swelling, allergic rhinitis, angioedema, laryngeal edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, urticaria, bullous pemphigus, photosensitivity, asthma, anaphylaxis, and others.
What can happen if you overdose with Generic Ponstel pills?
The symptoms of a mild overdose are the pain in the stomach, nausea, vomiting, and sleepiness. In severe overdose, gastrointestinal bleeding, breathing depression, arterial hypertension, and separate muscle spasms can occur.
There is no a specific antidote for this medication. The treatment implies vomiting and intake of activated carbon within an hour after the pills intake. Then, gastric lavage, urine alkalinization, forced diuresis, and symptomatic therapy is advised to be performed at a hospital if the symptoms are severe.
What are negative drug interactions with Ponstel?
Before you order Ponstel pills, make sure to check with your healthcare provider that you don’t take any medicines that are incompatible with this drug. In this article, you can find some of the most dangerous drug interactions but for the complete list please read the full instruction that comes with the pills.
The risk of gastrointestinal ulcers and bleeding is raised in the concurrent use of Generic Ponstel with corticosteroids, antiaggregant pills, selective serotonin reuptake inhibitors, oral anticoagulants, and other NSAIDs.
Cyclosporins, aminoglycosides, methotrexate, diuretics, and tacrolimus taken along with Mefenamic acid increase the risk of the toxic effect on the kidneys.
In combined use with cardiac glycosides, the enhancement of heart failure, kidney filtration function impairment, and increase the level of cardiac glycosides in blood plasma can occur.
Antihypertensive drugs taken along with this NSAD have a lower effect and increase the risk of renal failure, especially in elderly patients. Patients should consume enough fluids. It is also necessary to assess the function of the kidneys at the beginning of treatment and during the concomitant therapy.
If you take Mifepristone, you must avoid taking any NSAIDs within 8-12 days after you discontinued using Mifepristone as they significantly lower its effect.
The risk of joint hemorrhage and hematoma in HIV-positive hemophiliacs is increased in the simultaneous use of any NSAID with Zidovudine.
250 mg, 500mg
100 Pills, 150 Pills