Generic Retrovir (Zidovudine 100 mg) guide:
What is the medication you can buy as Generic Retrovir? Does it provide the same effect as the branded medicine?
If your doctor prescribed you Retrovir, you already know that this medication is used for the therapy of HIV. However, it is only a brand name. The active substance is called Zidovudine and it is the basis for multiple medications with the same effect. You can find such drugs when you look for Generic Retrovir. It is a collective term used by people who want to find a cheaper analog of Retrovir but do not know the other trade names under which the medicine is sold. Fortunately, this name is used not only by the customers, it is known by all pharmacists and doctors. So if you ask any pharmacist or doctor whether you can buy Generic Retrovir instead of the branded medicine, they will know exactly what you mean.
If you are worried about the effectiveness of the preparation, do not be! Generic medications are made according to the same formula and with the use of the same ingredients as the branded medicines. They are not fake medications like fake handbags or other accessories or garments made of inferior materials. Generics can be started to be manufactured only after the patent of the developer expires or if the patent stipulates that the developer of the drug must share the formula with other producers to make the medication more affordable and to satisfy the demand for the therapy. Although the main role of the generics is to make the most effective and modern treatment affordable for people from the developing countries, they can be also bought by people from the developed countries. Some generics are available in those countries at the regular drugstores. Others you can purchase from online drugstores that are located outside of your country. The purchase from the online stores like our allows you to save both on the visits to your doctor for a prescription and the medication itself because our prices are lower than in the U.S., the UK, and so on.
Why are generics cheaper, are they inferior?
Generic medications are cheaper first of all, as we have already mentioned, because they are made using the formula developed by other company so the generic drug maker doesn’t invest in the preparation development. Secondly, the manufacturers do not advertise their medications. Thirdly, they manufacture their preparations in such countries like India, China, or countries of the Eastern Europe where the labor force and general cost of production is lower.
Considering that none of this factors influence the quality of the medication, we can certainly say that you can buy Generic Zidovudine without any worries about the medication quality or effect.
When the preparation is used?
The main indication for the medication use is HIV and AIDS. These conditions significantly damage the immune system of the body and are respectively called human immunodeficiency virus and acquired immune deficiency syndrome. They are very dangerous conditions that make the body susceptible to all kinds of infections and severe development of even the mildest infections which can lead to death. Fortunately, today HIV is successfully suppressed to the extent that it cannot be transferred from a carrier to the sexual partner or from the mother to the baby in the womb. However, in order to suppress the condition, it is important to take timely tests and start the therapy.
In general, Retrovir is no longer the first-line therapy for the people with HIV who hadn’t received any antiretroviral therapy before. The medication causes adverse reactions that no more modern medicines cause and has a low effect in a single-drug therapy. However, it is still widely used due to its increased activity against certain strains of the virus and lack of the toxic effect on the central nervous system.
The medication is mostly used not for the therapy of HIV but as a prophylaxis and prevention of HIV transfer from the mother to the unborn baby and prevention of infection after a post-contact with HIV-positive partner or patient. Therefore, if you have any of these conditions and your doctor prescribes you the treatment course with Retrovir, you can buy Zidovudine at our online pharmacy instead of the branded medicine to save on the treatment while receiving the same effect. However, it is important to remember that the medication is commonly used as a part of combination therapy. Therefore, before you purchase the drug and start the treatment, make sure to clarify with your doctor what other preparations you need to use so you could order them at the same time with Zidovudine.
The virus is transmitted through three main pathways: during an unprotected sexual intercourse, from the infected mother to the unborn child, and through body fluids such as a contact of a wound with a HIV-positive individual’s blood, saliva, sperm, vaginal discharges, and so on.
Who cannot use the medication?
Although the medication is designed to treat one of the most dangerous commonly known conditions, it has certain contraindications for the use, they include: hypersensitivity (severe adverse reactions, allergic reactions to the drug’s components), severe neutropenia (low level of neutrophils in the blood), hypochromic anemia (color index of the blood, due to a lack of hemoglobin, is less than 0.8), myopathy (chronic progressive neuromuscular disease), and hepatomegaly with fatty dystrophy.
If you are unsure whether you have or do not have the conditions in which the medicine is contraindicated, you must consult a doctor who knows your disease history even though Retrovir can be prescribed to you by another doctor before you buy Retrovir.
How to use Generic Retrovir?
The medication is used in the same manner as the branded medication. Although in this medication guide we provide the general recommendations for the treatment regimen, you must clarify with your doctor whether you should follow the instruction or need any adjustments.
Therapy with Zidovudine only:
The starting dosage for the people with the body mass around 70 kg is 1.2 grams per day. The daily dosage is divided in 6 intakes. The maximum daily dosage is 1.5 grams. The maintenance dosage is 1 gram a day divided into 4-5 intakes. The correction of the maintenance dosage is made in accordance with the response of peripheral blood. The treatment must be discontinued if the level of hemoglobin is lower than 7.5 of if the number of neutrophils is less than 0.75*109. After these indicators are back to normal (usually, after a two week break) the treatment can be resumed.
The dosage for children is calculated taking into account the age and the body mass.
In combined therapy, the medication is taken in the dosage of 600 mg daily divided into two intakes.
What adverse reactions can you expect from Zidovudine use?
When you order Retrovir, you should be ready that the therapy can cause certain negative symptoms such as nausea, vomiting, pains in the abdomen, loss of appetite, dizziness, indigestion, fever, headache, insomnia, general weakness, muscle pain, skin rash, and violation of the blood composition.
In case you started experiencing any malaise and believe that it can be caused by the medication use, make sure to inform your doctor right away as some of the symptoms require urgent tests and possible discontinuation of the therapy.
Considering that the medication is able to cause blood composition changes, it is recommended to take blood tests every 2 weeks during the first 3 months of the therapy and not less than once a month further in the treatment. It is especially important to monitor blood condition during the therapy in patients with disorders of bone marrow function. In case of any worsening of the hematological parameters, a reduction of the dosage or complete discontinuation of the therapy is highly advised.
People with impaired liver function, including people with chronic active hepatitis, are at risk of worsening of the liver condition and require regular monitoring of the liver function. In case of the occurrence of liver diseases worsening signs, the interruption or cessation of the treatment should be considered.
Negative interactions with other medicines
Although the medication can and should be combined for the maximum effect with certain antiretroviral medications, it can negatively interact with other medicines such as flucanazole, probenecid, and paracetamol. The medication is incompatible with Stavudine.
The toxic effect on the bone marrow is increased in combined use with ganciclovir, vincristine, amphotericin B, cytotoxic agents, and other preparations depressing the bone marrow.
The overdose of the medication doesn’t manifest in any specific signs besides those listed in the adverse effects section. During the 1990s, the standard therapeutic dosages of Zidovudine greatly exceeded the currently used dosages and the reports on overdose didn’t show any serious health damage. However, if you do experience any severe reactions after you supposedly or certainly overdosed, you should inform your doctor or seek urgent medical assistance.
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